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- Title
CSF YKL-40 and GAP-43 are related to suicidal ideation in older women.
- Authors
Rymo, I.; Kern, S.; Bjerke, M.; Zetterberg, H.; Marlow, T.; Blennow, K.; Gudmundsson, P.; Skoog, I.; Waern, M.
- Abstract
Objective To investigate possible relationships between suicidal ideation and cerebrospinal fluid ( CSF) levels of glial markers YKL-40 (also known as chitinase-3-like protein 1), growth-associated protein-43 ( GAP-43) and myelin basic protein ( MBP). Method The sample was obtained from the Prospective Population Study of Women and included 86 women without dementia who underwent both psychiatric examinations and lumbar puncture ( LP). Eight of these women reported past-month suicidal ideation. Results Significantly, higher CSF levels of both YKL-40 and GAP-43 were detected in women with past-month suicidal ideation. Associations with suicidal ideation remained for both YKL-40 and GAP-43 in regression models adjusted for smoking status, BMI and age. CSF levels of YKL-40, GAP-43 and MBP did not differ by depression status. Higher levels of CSF GAP-43 were associated with feelings of worthlessness; a strong relationship was demonstrated in the fully adjusted model ( OR 5.95 CI [1.52-23.20], P = 0.01). Conclusion Our findings of elevated CSF concentrations of both YKL-40 and GAP-43 in women with suicidal ideation, compared to those without, suggest that a disrupted synaptic glial functioning and inflammation may be related to the aetiology of suicidal ideation in older adults.
- Subjects
SUICIDAL ideation; SELF-destructive behavior; MENTAL health of older women; CEREBROSPINAL fluid; DEPRESSION in women; PREVENTION
- Publication
Acta Psychiatrica Scandinavica, 2017, Vol 135, Issue 4, p351
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/acps.12701