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- Title
Dopamine transporter gene (DAT1) VNTR polymorphism in major psychiatric disorders: family-based association study in the Bulgarian population.
- Authors
Georgieva, L.; Dimitrova, A.; Nikolov, I.; Koleva, S.; Tsvetkova, R.; Owen, M. J.; Toncheva, D.; Kirov, G.
- Abstract
Objective: A 40-bp variable number tandem repeat in the 3′-UTR of dopamine transporter gene (DAT1 ) has been examined for association with major psychiatric disorders in several case–control studies. No significant results have been found. We used a new collection of parent–offspring trios to test for association with schizophrenia (SZ), bipolar 1 disorder (BPI) and schizoaffective (SA) disorder. Method: We genotyped trios from Bulgarian origin where the proband had SZ (178 trios), BPI (77 trios) and SA (29 trios). Alleles ranging from 5 to 11 repeats were observed. The results were analysed with the extended TDT (ETDT). Results: No preferential transmission of alleles was observed for any diagnostic group. The presence of allele DAT*10 was associated with the severity and frequency of auditory hallucinations, however, this result is not significant if corrected for multiple testing. Conclusion: Our results are in agreement with previous reports of a lack of association between this polymorphism and major psychiatric disorders.
- Subjects
DOPAMINE; PSYCHIATRY
- Publication
Acta Psychiatrica Scandinavica, 2002, Vol 105, Issue 5, p396
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1034/j.1600-0447.2002.1o174.x