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- Title
Randomized controlled trial of trimebutine (anal sphincter relaxant) for pain after haemorrhoidectomy.
- Authors
Ho, Y. H.; Seow-Choen, F.; Low, J. Y.; Tan, M.; Leong, A. P. K. F.
- Abstract
Background Anal sphincter spasm may aggravate pain after haemorrhoidectomy. The aims of this study were to investigate whether a trimebutine suppository (Proctolog) reduced anal resting pressure and, subsequently, to test its efficacy in relieving pain after haemorrhoidectomy. Methods Ten patients underwent anal manometry before and 4 h after Proctolog application. A controlled randomized trial was then conducted on 160 consecutive patients, A standard haemorrhoidectomy was performed. Eighty patients were then randomized to receive an application of Proctolog immediately after the procedure (group 1). The remaining 80 did not receive a suppository (controls, group 2). An independent, blinded observer determined the pain scores. Results Proctolog resulted in a mean 35 per cent reduction in resting anal pressure ( P 0.001). However, there were no differences in the pain score at 4 h after haemorrhoidectomy, maximum pain during the first 24 h, maximum pain during the second postoperative day, ketoprofen requirement or need for intramuscular pethidine injections between groups 1 and 2. Conclusion Although Proctolog reduced mean resting anal pressure at 4 h after application, this did not affect pain after haemorrhoidectomy.
- Publication
British Journal of Surgery, 1997, Vol 84, Issue 3, p377
- ISSN
0007-1323
- Publication type
Article
- DOI
10.1046/j.1365-2168.1997.02508.x