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- Title
Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic β-Cells: Human and In Vitro Evidence.
- Authors
Yu-Mi Lee; Chae-Myeong Ha; Se-A Kim; Thoudam, Themis; Young-Ran Yoon; Dae-Jung Kim; Hyeon-Chang Kim; Hyo-Bang Moon; Sungmi Park; In-Kyu Lee; Duk-Hee Lee; Lee, Yu-Mi; Ha, Chae-Myeong; Kim, Se-A; Yoon, Young-Ran; Kim, Dae-Jung; Kim, Hyeon-Chang; Moon, Hyo-Bang; Park, Sungmi; Lee, In-Kyu
- Abstract
Low-dose persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), have emerged as a new risk factor for type 2 diabetes. We evaluated whether chronic exposure to low-dose POPs affects insulin secretory function of β-cells in humans and in vitro cells. Serum concentrations of OCPs and PCBs were measured in 200 adults without diabetes. Mathematical model-based insulin secretion indices were estimated by using a 2-h seven-sample oral glucose tolerance test. Insulin secretion by INS-1E β-cells was measured after 48 h of treatment with three OCPs or one PCB mixture. Static second-phase insulin secretion significantly decreased with increasing serum concentrations of OCPs. Adjusted means were 63.2, 39.3, 44.1, 39.3, 39.7, and 22.3 across six categories of a summary measure of OCPs (Ptrend = 0.02). Dynamic first-phase insulin secretion remarkably decreased with increasing concentrations of OCPs among only insulin-sensitive individuals (Ptrend = 0.02); the insulin levels among individuals with high OCPs were ∼30% of those with low OCPs. Compared with OCPs, PCBs showed weaker associations. The decreased insulin secretion by INS-1E β-cells was observed for even 1 pmol/L OCP. The data from human and in vitro cell experiments suggest that chronic exposure to low-dose POPs, especially OCPs, can induce pancreatic β-cell dysfunction.
- Subjects
PERSISTENT pollutants; TYPE 2 diabetes risk factors; PHYSIOLOGICAL effects of pollutants; INSULIN; TYPE 2 diabetes; PHYSIOLOGY; ANIMALS; CELL lines; GLUCOSE tolerance tests; HYDROCARBONS; ISLANDS of Langerhans; POLLUTANTS; POLYCHLORINATED biphenyls; RATS
- Publication
Diabetes, 2017, Vol 66, Issue 10, p2669
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/db17-0188