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- Title
The Metabolic Syndrome in Mexican American Children: Preliminary Findings from the San Antonio Family Assessment of Metabolic Risk Indicators in Youth (SAFARI) Study.
- Authors
Duggirala, Ravindranath; Fowler, Sharon P.; Schneider, Jennifer; Puppala, Sobha; Farook, Vidya S.; Hunt, Kelly J.; Arya, Rector; Bradshaw, Benjamin; Almasy, Laura; Comuzzie, Anthony G.; Lynch, Jane L.; Jenkinson, Christopher P.; MacCluer, Jean W.; Defronzo, Ralph A.; Blangero, John; Hale, Daniel E.
- Abstract
The prevalence rates of obesity, type 2 diabetes (T2DM), and the Metabolic Syndrome (MS) have been increasing at alarming rates in children. We are conducting a community-based study, called SAFARI, to determine the precursors of MS in Mexican American children; compare MS profiles between these children and adult members of their families; and verify whether variants in candidate genes found to be associated with MS traits in adults have any relevance to similar traits in children. Our study participants are the children (aged 6-17 years) of adult members of three well-established San Antonio-based Mexican American family studies. As of 12-12-2006, 219 children had participated (111 girls and 108 boys, mean age = 12 years) in our study. A variety of data - metabolic, anthropometric, behavioral, and dietary - have been collected from each child; comparable metabolic and anthropometric data were collected for their parents and other adults in their extended families. The prevalence rates of T2DM, impaired fasting glucose, and impaired glucose tolerance are ∼0.5%, ∼9% and ∼ 18%, respectively. The mean body mass index [BMI: kg/m²] is ∼23. About 48% of the children are at risk of being overweight and ∼32% are overweight. Several of the phenotypes have shown significant heritabilities [p-value] (e.g., fasting glucose = 28% [0.04], BMI = 72% [0.00003], total cholesterol = 54% [0.003], triglycerides = 79% [0.0006], systolic blood pressure = 62% [0.0003], and urine albumin/creatinine ratio = 58% [0.003]). In conclusion, these preliminary data reveal a high risk of overweight in almost half the Mexican American children studied, an alarming occurrence of pre-diabetes in these children, and strong genetic influences over key MS-related traits.
- Subjects
METABOLIC syndrome; HEALTH risk assessment; CHILDHOOD obesity; TYPE 2 diabetes; MEXICAN American children; GLUCOSE; BODY mass index; PREDIABETIC state; DISEASES
- Publication
Diabetes, 2007, Vol 56, pA489
- ISSN
0012-1797
- Publication type
Article