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- Title
Soluble CD40 Ligand and C-Reactive Protein Concentrations Are Affected by Glucose and Insulin Levels in Subjects with Essential Hypertension.
- Authors
Penno, Giuseppe; Miccoli, Roberto; Pedrinelli, Roberto; Pucci, Laura; Santini, Eleonora; Dell'omo, Giulia; Lucchesi, Daniela; Ferrannini, Eleuterio; del Prato, Stefano; Solini, Anna
- Abstract
Subclinical inflammation and platelets activation are involved in the patho-physiology of cardiovascular disease (CVD). Recently both sCD40L (released by activated platelets) and hs-CRP (an inflammatory marker) have been reported higher among hypertensive patients, but factors affecting both parameters are poorly understood. We aimed to measure hs-CRP and sCD40L in 89 CVD event-free men with essential hypertension and normal renal function, and to explore CVD risk factors affecting circulating levels of hs-CRP and sCD40L with emphasis to Metabolic Syndrome (MS) components. We studied 89 patients (age 49±11 yrs, range of BMI: 18.4-34.5 kg/m2, creatinine below 1.2 mg/dl and cystatin-C ranging from 0.53 to 1.18 mg/1). All subjects underwent a 24 hour ABPM and an OGTT. Specific immnnoassay were used for sCD40L and hs-CRP. Among these subjects, 18% had IFG, 8% IGT, 5% both conditions. MS (NCEP/ATPIII criteria) was present in 30 out of 89 subjects (34%). Mean levels of hs-CRP were 2.4±2.3 (range 0.4 to 8.5) ng/ml; mean levels of sCD40L 8.8±5:0 (range 0.8 to 18.5) ng/ml. No correlation was observed between hs-CRP and sCD40L (p=0.97) and no differences in both parameters emerged in subjects with and without MS. Neither hs-CRP and sCD40L did correlate with age, BMI, systolic and diastolic 24h ABPM parameters, renal function indexes or urinary albumin excretion. Within lipid parameters, a weak positive regression was observed between total cholesterol and sCD40L (p=0.047). hs-CRP correlated with fibrinogen levels (p<0.0001). sCD40L positively correlated with fasting glucose (r=0.23, p=0.029), basal insulin levels (r=0.34, p=0.002), and HOMA-IR (r=0.37, p=0.001), while hs-CRP weakly correlated with the insulinogenic index (r=0.25, p=0.05) and the area under the OGTT curve for insulin (r=0.32, p=0.027). In a multiple regression model, HOMA-IR emerged as the main determinant of the variability of sCD40L levels, while AUC insulin was the main determinant of the variability of hs-CRP concentrations. In conclusion, minor changes in glucose and insulin metabolism might account at least in part for the inflammatory disorders related to essential hypertension.
- Subjects
LIGANDS (Biochemistry); C-reactive protein; GLUCOSE; INSULIN; PATIENTS; HYPERTENSION; BLOOD platelets; CARDIOVASCULAR diseases
- Publication
Diabetes, 2007, Vol 56, pA195
- ISSN
0012-1797
- Publication type
Article