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- Title
Genomic Insights and Synthetic Biology Applications of Marine Actinomycete Streptomyces griseoincarnatus HNS054.
- Authors
Wang, Qinghua; Zhao, Jing; Liu, Zhaoyuan; Ding, Shaoxiong; Huang, Zhiyong; Chen, Jun
- Abstract
The marine bacterium Streptomyces sp. HNS054 shows promise as a platform for producing natural products. Isolated from a marine sponge, HNS054 possesses several desirable traits for bioengineering: rapid growth, salt tolerance, and compatibility with genetic tools. Its genome contains 21 potential biosynthetic gene clusters, offering a rich source of natural products. We successfully engineered HNS054 to increase the production of aborycin and actinorhodin by 4.5-fold and 1.2-fold, respectively, compared to S. coelicolor M1346 counterparts. With its unique features and amenability to genetic manipulation, HNS054 emerges as a promising candidate for developing novel marine-derived drugs and other valuable compounds.
- Subjects
MARINE biology; STREPTOMYCES; NATURAL products; MARINE bacteria; GENE clusters; SYNTHETIC biology
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 6, p3127
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25063127