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- Title
Systematic Review: Targeted Molecular Imaging of Angiogenesis and Its Mediators in Rheumatoid Arthritis.
- Authors
Khodadust, Fatemeh; Ezdoglian, Aiarpi; Steinz, Maarten M.; van Beijnum, Judy R.; Zwezerijnen, Gerben J. C.; Jansen, Gerrit; Tas, Sander W.; van der Laken, Conny J.
- Abstract
Extensive angiogenesis is a characteristic feature in the synovial tissue of rheumatoid arthritis (RA) from a very early stage of the disease onward and constitutes a crucial event for the development of the proliferative synovium. This process is markedly intensified in patients with prolonged disease duration, high disease activity, disease severity, and significant inflammatory cell infiltration. Angiogenesis is therefore an interesting target for the development of new therapeutic approaches as well as disease monitoring strategies in RA. To this end, nuclear imaging modalities represent valuable non-invasive tools that can selectively target molecular markers of angiogenesis and accurately and quantitatively track molecular changes in multiple joints simultaneously. This systematic review summarizes the imaging markers used for single photon emission computed tomography (SPECT) and/or positron emission tomography (PET) approaches, targeting pathways and mediators involved in synovial neo-angiogenesis in RA.
- Subjects
SINGLE-photon emission computed tomography; CARDIAC radionuclide imaging; RHEUMATOID arthritis; POSITRON emission tomography; NEOVASCULARIZATION
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 13, p7071
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23137071