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- Title
Supplementary Materials: miR-30-5p Regulates Muscle Differentiation and Alternative Splicing of Muscle-Related Genes by Targeting MBNL.
- Authors
Bo-Wen Zhang; Han-Fang Cai; Xue-Feng Wei; Jia-Jie Sun; Xian-Yong Lan; Chu-Zhao Lei; Feng-Peng Lin; Xing-Lei Qi; Plath, Martin; Hong Chen
- Abstract
The article presents a study on the role of the microRNA (miR)-30-5p family during bovine muscle development from previous high-throughput sequencing results. The study reveals that miR-30a-5p and miR-30e-5p repress the expression of MBNL1, MBNL2 and MBNL3, whereas miR-30b-5p inhibits protein expression for MBNL1 and MBNL2. The capability of miR-30-5p to inhibit muscle cell differentiation and regulate the alternative splicing of Trim55 and INSR by targeting MBNL is tackled.
- Subjects
MICRORNA; MUSCLE growth; BOS; NUCLEOTIDE sequencing; PROTEIN expression; CELL differentiation
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 2, pS1
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17020182