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- Title
Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus.
- Authors
Kongyang Ma; Jingyi Li; Yongfei Fang; Liwei Lu
- Abstract
Toll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.
- Subjects
TOLL-like receptors; PATTERN perception; SYSTEMIC lupus erythematosus; B cells; AUTOANTIBODIES
- Publication
International Journal of Molecular Sciences, 2015, Vol 16, Issue 6, p13084
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms160613084