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- Title
Effects of Hydroxylpropyl-β-Cyclodextrin on in Vitro Insulin Stability.
- Authors
Liefeng Zhang; Wenjie Zhu; Lingling Song; Yifan Wang; Hui Jiang; Suyun Xian; Yong Ren
- Abstract
The objective of this study was to elucidate the effects of hydroxylpropyl-β- cyclodextrin (HP-β-CD) on the in vitro stability of insulin. It was found that HP-β-CD had positive effects on the stability of insulin in acid and base and under high temperature conditions. Furthermore, use of HP-β-CD could also increase the stability of disulfide bonds which are important to the conformation of insulin. Through ¹H-NMR experiments it was found that the protective effect of HP-β-CD was due to complexation with insulin. The results suggest that the presence of HP-β-CD could improve the stability of insulin in different environments.
- Subjects
INSULIN stability; CYCLODEXTRINS; HYPOGLYCEMIC agents; PANCREATIC secretions; INSULIN therapy
- Publication
International Journal of Molecular Sciences, 2009, Vol 10, Issue 5, p2031
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms10052031