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- Title
Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma.
- Authors
Konstantinopoulos, Panagiotis A.; Dezube, Bruce J.; Pantanowitz, Liron
- Abstract
Background: The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions. Case Presentation: We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic lymphedema in an HIV-positive patient. Spindle-shaped and endothelial cells in these early KS-appearing lesions were immunoreactive for HHV8, D2-40 and CD34. Conclusion: Our findings suggest that HHV8-infected spindle-shaped cells associated with lymphangiogenesis that evolve into KS lesions, acquire from the outset an aberrant mixed vascular and lymphatic endothelial cell phenotype.
- Subjects
KAPOSI'S sarcoma; PRECANCEROUS conditions; SARCOMA; CANCER; PATHOLOGY
- Publication
BMC Clinical Pathology, 2006, Vol 6, p7
- ISSN
1472-6890
- Publication type
Article
- DOI
10.1186/1472-6890-6-7