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- Title
Polycyclic N-Heterocyclic Compounds 73: Synthesis and Evaluation of 5-Substituted 1,2-Dihydrofuro[2,3- c]isoquinolines as Inducers of Lipoprotein Lipase mRNA Expression.
- Authors
Okuda, KENsuke; Yoshida, Masahiko; Hirota, Takashi; Sasaki, KENji
- Abstract
Several 5-substituted 1,2-dihydro[2,3- c]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th-position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3-L1 preadipocytes revealed one promising candidate with potency comparable to that of .
- Subjects
POLYCYCLIC compounds; HETEROCYCLIC compounds; ISOQUINOLINE synthesis; LIPOPROTEIN lipase; MESSENGER RNA; GENE expression; QUINOLINE derivatives; ISOQUINOLINE; HYPOGLYCEMIC agents
- Publication
Journal of Heterocyclic Chemistry, 2013, Vol 50, pE9
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1016