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- Title
Quantitative evaluation of renal parenchymal perfusion using contrast-enhanced ultrasonography in renal ischemia-reperfusion injury in dogs.
- Authors
Gahyun Lee; Sunghoon Jeon; Sang-kwon Lee; Byunggyu Cheon; Sohyeon Moon; Jun-Gyu Park; Kyoung-Oh Cho; Jihye Choi
- Abstract
This study evaluated whether renal perfusion changes can be noninvasively estimated by using contrast-enhanced ultrasonography (CEUS) in renal ischemia-reperfusion injury and investigated the correlation between renal perfusion measured by CEUS and necrosis and apoptosis of renal tubular epithelial cells, hr six dogs with experimentally induced renal ischemia-reperfusion injury, changes in time to peak intensity, peak intensity, and area under the curve were measured on CEUS. Peak intensity and area under the curve of the renal cortex began to decrease on day 1 (about 20% lower than baseline) and reached the lowest levels (about 50% of baseline) on day 4. They then gradually increased until day 10, at which time peak intensity was about 87% and area under the curve was about 95% of baseline; neither fully recovered. Both parameters were strongly correlated with the necrosis scores on histopathologic examination on day 4 (r = --0.810 of peak intensity and r = --0.886 of area under the curve). CEUS allowed quantitative evaluation of perfusion changes in acute renal ischemia-reperfusion injury, and CEUS results were correlated with renal tubular damage on histopathologic examination. Thus, CEUS could be a noninvasive, quantitative diagnostic method for determining progress of renal ischemia-reperfusion injury.
- Subjects
DOGS' injuries; KIDNEY injuries; CONTRAST-enhanced ultrasound; REPERFUSION injury; APOPTOSIS
- Publication
Journal of Veterinary Science, 2017, Vol 18, Issue 4, p507
- ISSN
1229-845X
- Publication type
Article
- DOI
10.4142/jvs.2017.18.4.507