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- Title
Stereoselective Heck Reactions with Vinyl Sulfoxides, Sulfides and Sulfones.
- Authors
Bachmann, Daniel G.; Wittwer, Christopher C.; Gillingham, Dennis G.
- Abstract
We report the Heck cross-coupling of notoriously unreactive, but synthetically valuable olefins: vinyl sulfoxides, vinyl sulfones, and vinyl sulfides. Key findings include the importance of the sterically hindered (tri- tert-butyl)phosphine ligand and the unique effectiveness of triethylamine as the base. The method is general, E-selective, and can be used to synthesize disubstituted or trisubstituted olefins through simple adjustments of stoichiometry.
- Subjects
STEREOSELECTIVE reactions; SULFOXIDES; SULFIDES; TRIETHYLAMINE; LIGANDS (Chemistry); STOICHIOMETRY
- Publication
Advanced Synthesis & Catalysis, 2013, Vol 355, Issue 18, p3703
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201300678