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Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma.
Published in:
Journal of Personalized Medicine, 2020, v. 10, n. 4, p. 1, doi. 10.3390/jpm10040290
By:
- Mayr, Lisa;
- Guntner, Armin S.;
- Madlener, Sibylle;
- Schmook, Maria T.;
- Peyrl, Andreas;
- Azizi, Amedeo A.;
- Dieckmann, Karin;
- Reisinger, Dominik;
- Stepien, Natalia M.;
- Schramm, Kathrin;
- Laemmerer, Anna;
- Jones, David T. W.;
- Ecker, Jonas;
- Sahm, Felix;
- Milde, Till;
- Pajtler, Kristian W.;
- Blattner-Johnson, Mirjam;
- Strbac, Miroslav;
- Dorfer, Christian;
- Czech, Thomas
Publication type:
Article
Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25708-y
By:
- Deng, Maximilian Y.;
- Sturm, Dominik;
- Pfaff, Elke;
- Sill, Martin;
- Stichel, Damian;
- Balasubramanian, Gnana Prakash;
- Tippelt, Stephan;
- Kramm, Christof;
- Donson, Andrew M.;
- Green, Adam L.;
- Jones, Chris;
- Schittenhelm, Jens;
- Ebinger, Martin;
- Schuhmann, Martin U.;
- Jones, Barbara C.;
- van Tilburg, Cornelis M.;
- Wittmann, Andrea;
- Golanov, Andrey;
- Ryzhova, Marina;
- Ecker, Jonas
Publication type:
Article
Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma.
Published in:
Acta Neuropathologica Communications, 2015, v. 3, n. 1, p. 121, doi. 10.1186/s40478-015-0201-7
By:
- Ecker, Jonas;
- Oehme, Ina;
- Mazitschek, Ralph;
- Korshunov, Andrey;
- Kool, Marcel;
- Hielscher, Thomas;
- Kiss, Judit;
- Selt, Florian;
- Konrad, Carina;
- Lodrini, Marco;
- Deubzer, Hedwig E.;
- von Deimling, Andreas;
- Kulozik, Andreas E.;
- Pfister, Stefan M.;
- Witt, Olaf;
- Milde, Till
Publication type:
Article
MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40235-8
By:
- Sigaud, Romain;
- Albert, Thomas K.;
- Hess, Caroline;
- Hielscher, Thomas;
- Winkler, Nadine;
- Kocher, Daniela;
- Walter, Carolin;
- Münter, Daniel;
- Selt, Florian;
- Usta, Diren;
- Ecker, Jonas;
- Brentrup, Angela;
- Hasselblatt, Martin;
- Thomas, Christian;
- Varghese, Julian;
- Capper, David;
- Thomale, Ulrich W.;
- Hernáiz Driever, Pablo;
- Simon, Michèle;
- Horn, Svea
Publication type:
Article
Accurate calling of KIAA1549‐BRAF fusions from DNA of human brain tumours using methylation array‐based copy number and gene panel sequencing data.
Published in:
Neuropathology & Applied Neurobiology, 2021, v. 47, n. 3, p. 406, doi. 10.1111/nan.12683
By:
- Stichel, Damian;
- Schrimpf, Daniel;
- Sievers, Philipp;
- Reinhardt, Annekathrin;
- Suwala, Abigail K.;
- Sill, Martin;
- Reuss, David E.;
- Korshunov, Andrey;
- Casalini, Belén M.;
- Sommerkamp, Alexander C.;
- Ecker, Jonas;
- Selt, Florian;
- Sturm, Dominik;
- Gnekow, Astrid;
- Koch, Arend;
- Simon, Michèle;
- Hernáiz Driever, Pablo;
- Schüller, Ulrich;
- Capper, David;
- Tilburg, Cornelis M.
Publication type:
Article
Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma.
Published in:
Neuro-Oncology, 2021, v. 23, n. 2, p. 226, doi. 10.1093/neuonc/noaa191
By:
- Ecker, Jonas;
- Thatikonda, Venu;
- Sigismondo, Gianluca;
- Selt, Florian;
- Valinciute, Gintvile;
- Oehme, Ina;
- Müller, Carina;
- Buhl, Juliane L;
- Ridinger, Johannes;
- Usta, Diren;
- Qin, Nan;
- Tilburg, Cornelis M van;
- Herold-Mende, Christel;
- Remke, Marc;
- Sahm, Felix;
- Westermann, Frank;
- Kool, Marcel;
- Wechsler-Reya, Robert J;
- Chavez, Lukas;
- Krijgsveld, Jeroen
Publication type:
Article
MEDU-01. HDACi AND PLK1i ACT SYNERGISTICALLY IN MYC-AMPLIFIED MEDULLOBLASTOMA.
Published in:
Neuro-Oncology, 2019, v. 21, p. ii103, doi. 10.1093/neuonc/noz036.161
By:
- Valinciute, Gintvile;
- Ecker, Jonas;
- Hielscher, Thomas;
- Schmidt, Christin;
- Remke, Marc;
- Sigismondo, Gianluca;
- Krijgsveld, Jeroen;
- Pfister, Stefan;
- Witt, Olaf;
- Milde, Till
Publication type:
Article
GENE-12. ANAPLASTIC NEUROEPITHELIAL TUMOR WITH CONDENSED NUCLEI (ANTCON): A NOVEL BRAIN TUMOR ENTITY WITH RECURRENT NTRK FUSION.
Published in:
Neuro-Oncology, 2019, v. 21, p. ii83, doi. 10.1093/neuonc/noz036.083
By:
- Jones, David;
- Ismer, Britta;
- Schrimpf, Daniel;
- Reuss, David;
- Stichel, Damien;
- Casalini, Belen;
- Schittenhelm, Jens;
- Frank, Stephan;
- Boldt, Henning;
- Winther-Kristensen, Bjarne;
- Sehested, Astrid Marie;
- Scheie, David;
- Korshunov, Andrey;
- Ecker, Jonas;
- Milde, Till;
- Pajtler, Kristian;
- Herold-Mende, Christel;
- Witt, Olaf;
- Wick, Wolfgang;
- Pfister, Stefan M
Publication type:
Article
A synergistic interaction between HDAC‐ and PARP inhibitors in childhood tumors with chromothripsis.
Published in:
International Journal of Cancer, 2022, v. 151, n. 4, p. 590, doi. 10.1002/ijc.34027
By:
- Khalid, Umar;
- Simovic, Milena;
- Hammann, Linda A.;
- Iskar, Murat;
- Wong, John K. L.;
- Kumar, Rithu;
- Jugold, Manfred;
- Sill, Martin;
- Bolkestein, Michiel;
- Kolb, Thorsten;
- Hergt, Michaela;
- Devens, Frauke;
- Ecker, Jonas;
- Kool, Marcel;
- Milde, Till;
- Westermann, Frank;
- Benner, Axel;
- Lewis, Joe;
- Dietrich, Sascha;
- Pfister, Stefan M.
Publication type:
Article
Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors.
Published in:
Brain Pathology, 2016, v. 26, n. 4, p. 506, doi. 10.1111/bpa.12326
By:
- Selt, Florian;
- Deiß, Alica;
- Korshunov, Andrey;
- Capper, David;
- Witt, Hendrik;
- van Tilburg, Cornelis M.;
- Jones, David T. W.;
- Witt, Ruth;
- Sahm, Felix;
- Reuss, David;
- Kölsche, Christian;
- Ecker, Jonas;
- Oehme, Ina;
- Hielscher, Thomas;
- von Deimling, Andreas;
- Kulozik, Andreas E.;
- Pfister, Stefan M.;
- Witt, Olaf;
- Milde, Till
Publication type:
Article
Key Pharmacokinetic Parameters of 74 Pediatric Anticancer Drugs Providing Assistance in Preclinical Studies.
Published in:
Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 4, p. 904, doi. 10.1002/cpt.3002
By:
- Jamaladdin, Nora;
- Sigaud, Romain;
- Kocher, Daniela;
- Kolodziejczak, Anna S.;
- Nonnenbroich, Leo F.;
- Ecker, Jonas;
- Usta, Diren;
- Benzel, Julia;
- Peterziel, Heike;
- Pajtler, Kristian W.;
- van Tilburg, Cornelis M.;
- Oehme, Ina;
- Witt, Olaf;
- Milde, Till
Publication type:
Article
Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia.
Published in:
Clinical Epigenetics, 2019, v. 11, n. 1, p. 1, doi. 10.1186/s13148-019-0775-1
By:
- van Tilburg, Cornelis M.;
- Milde, Till;
- Witt, Ruth;
- Ecker, Jonas;
- Hielscher, Thomas;
- Seitz, Angelika;
- Schenk, Jens-Peter;
- Buhl, Juliane L.;
- Riehl, Dennis;
- Frühwald, Michael C.;
- Pekrun, Arnulf;
- Rossig, Claudia;
- Wieland, Regina;
- Flotho, Christian;
- Kordes, Uwe;
- Gruhn, Bernd;
- Simon, Thorsten;
- Linderkamp, Christin;
- Sahm, Felix;
- Taylor, Lenka
Publication type:
Article
Retinoblastoma with late metastatic spread-a case report.
Published in:
2019
By:
- Hofer, Silvia;
- Diebold, Joachim;
- Temming, Petra;
- Lohmann, Dietmar;
- Howell, Jeremy;
- Moulin, Alexandre;
- Beck‐Popovic, Maja;
- Sahm, Felix;
- Milde, Till;
- Ecker, Jonas;
- Beck-Popovic, Maja
Publication type:
Case Study
Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.
Published in:
Acta Neuropathologica, 2023, v. 145, n. 5, p. 667, doi. 10.1007/s00401-023-02558-0
By:
- Bogumil, Henri;
- Sill, Martin;
- Schrimpf, Daniel;
- Ismer, Britta;
- Blume, Christina;
- Rahmanzade, Ramin;
- Hinz, Felix;
- Cherkezov, Asan;
- Banan, Rouzbeh;
- Friedel, Dennis;
- Reuss, David E.;
- Selt, Florian;
- Ecker, Jonas;
- Milde, Till;
- Pajtler, Kristian W.;
- Schittenhelm, Jens;
- Hench, Jürgen;
- Frank, Stephan;
- Boldt, Henning B.;
- Kristensen, Bjarne Winther
Publication type:
Article
Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts.
Published in:
Acta Neuropathologica, 2023, v. 145, n. 1, p. 97, doi. 10.1007/s00401-022-02522-4
By:
- Mynarek, Martin;
- Obrecht, Denise;
- Sill, Martin;
- Sturm, Dominik;
- Kloth-Stachnau, Katja;
- Selt, Florian;
- Ecker, Jonas;
- von Hoff, Katja;
- Juhnke, Björn-Ole;
- Goschzik, Tobias;
- Pietsch, Torsten;
- Bockmayr, Michael;
- Kool, Marcel;
- von Deimling, Andreas;
- Witt, Olaf;
- Schüller, Ulrich;
- Benesch, Martin;
- Gerber, Nicolas U.;
- Sahm, Felix;
- Jones, David T. W.
Publication type:
Article
GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types.
Published in:
Acta Neuropathologica, 2021, v. 142, n. 6, p. 1065, doi. 10.1007/s00401-021-02369-1
By:
- Sievers, Philipp;
- Stichel, Damian;
- Sill, Martin;
- Schrimpf, Daniel;
- Sturm, Dominik;
- Selt, Florian;
- Ecker, Jonas;
- Kazdal, Daniel;
- Miele, Evelina;
- Kranendonk, Mariëtte E. G.;
- Tops, Bastiaan B. J.;
- Kohlhof-Meinecke, Patricia;
- Beschorner, Rudi;
- Kramm, Christof M.;
- Hasselblatt, Martin;
- Reifenberger, Guido;
- Capper, David;
- Wesseling, Pieter;
- Stenzinger, Albrecht;
- Milde, Till
Publication type:
Article
Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions.
Published in:
Acta Neuropathologica, 2019, v. 138, n. 5, p. 827, doi. 10.1007/s00401-019-02039-3
By:
- Stichel, Damian;
- Schrimpf, Daniel;
- Casalini, Belén;
- Meyer, Jochen;
- Wefers, Annika K.;
- Sievers, Philipp;
- Korshunov, Andrey;
- Koelsche, Christian;
- Reuss, David E.;
- Reinhardt, Annekathrin;
- Ebrahimi, Azadeh;
- Fernández-Klett, Francisco;
- Kessler, Tobias;
- Sturm, Dominik;
- Ecker, Jonas;
- Milde, Till;
- Herold-Mende, Christel;
- Witt, Olaf;
- Pfister, Stefan M.;
- Wick, Wolfgang
Publication type:
Article
Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells.
Published in:
Journal of Neuro-Oncology, 2024, v. 166, n. 1, p. 99, doi. 10.1007/s11060-023-04526-w
By:
- Zeuner, Simon;
- Vollmer, Johanna;
- Sigaud, Romain;
- Oppermann, Sina;
- Peterziel, Heike;
- ElHarouni, Dina;
- Oehme, Ina;
- Witt, Olaf;
- Milde, Till;
- Ecker, Jonas
Publication type:
Article
Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow.
Published in:
Journal of Neuro-Oncology, 2023, v. 165, n. 3, p. 467, doi. 10.1007/s11060-023-04500-6
By:
- Selt, Florian;
- El Damaty, Ahmed;
- Schuhmann, Martin U.;
- Sigaud, Romain;
- Ecker, Jonas;
- Sievers, Philipp;
- Kocher, Daniela;
- Herold-Mende, Christel;
- Oehme, Ina;
- von Deimling, Andreas;
- Pfister, Stefan M.;
- Sahm, Felix;
- Jones, David T. W.;
- Witt, Olaf;
- Milde, Till
Publication type:
Article
Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells.
Published in:
Journal of Neuro-Oncology, 2023, v. 164, n. 3, p. 617, doi. 10.1007/s11060-023-04445-w
By:
- Vollmer, Johanna;
- Ecker, Jonas;
- Hielscher, Thomas;
- Valinciute, Gintvile;
- Ridinger, Johannes;
- Jamaladdin, Nora;
- Peterziel, Heike;
- van Tilburg, Cornelis M.;
- Oehme, Ina;
- Witt, Olaf;
- Milde, Till
Publication type:
Article
Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells.
Published in:
Journal of Neuro-Oncology, 2023, v. 163, n. 1, p. 143, doi. 10.1007/s11060-023-04319-1
By:
- Valinciute, Gintvile;
- Ecker, Jonas;
- Selt, Florian;
- Hielscher, Thomas;
- Sigaud, Romain;
- Ridinger, Johannes;
- Thatikonda, Venu;
- Gatzweiler, Charlotte;
- Robinson, Sarah;
- Talbot, Julie;
- Bernardi, Flavia;
- Picard, Daniel;
- Blattner-Johnson, Mirjam;
- Schmid, Simone;
- Jones, David T.;
- van Tilburg, Cornelis M.;
- Capper, David;
- Kool, Marcel;
- Remke, Marc;
- Oehme, Ina
Publication type:
Article
Response to trametinib treatment in progressive pediatric low-grade glioma patients.
Published in:
Journal of Neuro-Oncology, 2020, v. 149, n. 3, p. 499, doi. 10.1007/s11060-020-03640-3
By:
- Selt, Florian;
- van Tilburg, Cornelis M.;
- Bison, Brigitte;
- Sievers, Philipp;
- Harting, Inga;
- Ecker, Jonas;
- Pajtler, Kristian W.;
- Sahm, Felix;
- Bahr, Annabelle;
- Simon, Michèle;
- Jones, David T. W.;
- Well, Lennart;
- Mautner, Victor-Felix;
- Capper, David;
- Hernáiz Driever, Pablo;
- Gnekow, Astrid;
- Pfister, Stefan M.;
- Witt, Olaf;
- Milde, Till
Publication type:
Article
Clinical outcome of pediatric medulloblastoma patients with Li–Fraumeni syndrome.
Published in:
Neuro-Oncology, 2023, v. 25, n. 12, p. 2273, doi. 10.1093/neuonc/noad114
By:
- Kolodziejczak, Anna S;
- Guerrini-Rousseau, Lea;
- Planchon, Julien Masliah;
- Ecker, Jonas;
- Selt, Florian;
- Mynarek, Martin;
- Obrecht, Denise;
- Sill, Martin;
- Autry, Robert J;
- Stutheit-Zhao, Eric;
- Hirsch, Steffen;
- Amouyal, Elsa;
- Dufour, Christelle;
- Ayrault, Olivier;
- Torrejon, Jacob;
- Waszak, Sebastian M;
- Ramaswamy, Vijay;
- Pentikainen, Virve;
- Demir, Haci Ahmet;
- Clifford, Steven C
Publication type:
Article
Sarcoma classification by DNA methylation profiling.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20603-4
By:
- Koelsche, Christian;
- Schrimpf, Daniel;
- Stichel, Damian;
- Sill, Martin;
- Sahm, Felix;
- Reuss, David E.;
- Blattner, Mirjam;
- Worst, Barbara;
- Heilig, Christoph E.;
- Beck, Katja;
- Horak, Peter;
- Kreutzfeldt, Simon;
- Paff, Elke;
- Stark, Sebastian;
- Johann, Pascal;
- Selt, Florian;
- Ecker, Jonas;
- Sturm, Dominik;
- Pajtler, Kristian W.;
- Reinhardt, Annekathrin
Publication type:
Article

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