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- Title
Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study.
- Authors
Carbone, Laura; Bůžková, Petra; Fink, Howard; Robbins, John; Bethel, Monique; Hamrick, Mark; Hill, William; Carbone, Laura D; Bůžková, Petra; Fink, Howard A; Robbins, John A; Hamrick, Mark W; Hill, William D
- Abstract
Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone formation and BMSC differentiation into osteoblasts/osteocytes, and in osteoprogenitor cell survival. The objective of this study was to examine the association of plasma SDF-1 in participants in the cardiovascular health study (CHS) with bone mineral density (BMD), body composition, and incident hip fractures. In 1536 CHS participants, SDF-1 plasma levels were significantly associated with increasing age (p < 0.01) and male gender (p = 0.04), but not with race (p = 0.63). In multivariable-adjusted models, higher SDF-1 levels were associated with lower total hip BMD (p = 0.02). However, there was no significant association of SDF-1 with hip fractures (p = 0.53). In summary, circulating plasma levels of SDF-1 are associated with increasing age and independently associated with lower total hip BMD in both men and women. These findings suggest that SDF-1 levels are linked to bone homeostasis.
- Subjects
BONE density; BODY composition; AGING; STROMAL cells; OSTEOBLASTS; BONE metabolism; CARDIOVASCULAR diseases; CYTOKINES; BONE fractures; HIP joint injuries; MACROPHAGES; RESEARCH funding; SEX distribution
- Publication
Calcified Tissue International, 2017, Vol 100, Issue 6, p599
- ISSN
0171-967X
- Publication type
journal article
- DOI
10.1007/s00223-017-0245-8