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- Title
A observational study of the efficacy and safety of capecitabine versus bolus infusional 5-fluorouracil in pre-operative chemoradiotherapy for locally advanced rectal cancer.
- Authors
Chen, Chin-Fan; Huang, Ming-Yii; Huang, Chih-Jen; Wu, Chan-Han; Yeh, Yung-Sung; Tsai, Hsiang-Lin; Ma, Cheng-Jen; Lu, Chien-Yu; Chang, Shun-Jen; Chen, Ming-Jenn; Wang, Jaw-Yuan
- Abstract
Background and objectives: This study is to evaluate the safety and efficacy of preoperative radiotherapy (RT) combined with bolus infusional 5-fluorouracil (5-FU) or oral capecitabine in patients with locally advanced rectal cancer (LARC). Materials and methods: Seventy-four patients were retrospectively analyzed. Twenty-seven patients were treated with 5-FU (350 mg/m IV bolus) and leucovorin (20 mg/m IV bolus) for 5 days/week during week 1 and 5 of RT. Forty-seven patients were treated with capecitabine (850 mg/m, twice daily for 5 days/week). Both groups received the same RT course (45-50.4 Gy/25 fractions, 5 days/week, for 5 weeks). Patients underwent surgery in 6 weeks after completion of the chemoradiotherapy. Data of the observational study were collected. Results: Grade 3 or 4 toxicities occurred in 40.7% (5-FU) and 19.1% (capecitabine) of the patients ( P = 0.044). Six patients in the 5-FU group (22.2%) and six patients in the capecitabine group (14%) achieved complete response. Primary tumor (T) downstaging were achieved in 51.9% (5-FU) and 69.8% (capecitabine) of the patients. The pathological ypT0-2 stage was 40.7% (5-FU) and 67.4% (capecitabine) ( P = 0.028). Conclusions: In consideration of the better ypT0-2 downstaging rate, less severe toxicities, and no need for indwelling intravenous device on oral capecitabine regimen, the administration of oral capecitabine with RT may be a more favorable option in the neoadjuvant treatment for LARC.
- Subjects
DRUG efficacy; FLUOROURACIL; RECTAL cancer treatment; FOLINIC acid; CANCER radiotherapy
- Publication
International Journal of Colorectal Disease, 2012, Vol 27, Issue 6, p727
- ISSN
0179-1958
- Publication type
Article
- DOI
10.1007/s00384-011-1377-3