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- Title
Levels of Soluble Triggering Receptor Expressed on Myeloid Cells 1 in Infectious Exacerbations of Chronic Obstructive Pulmonary Disease.
- Authors
Rohde, Gernot; Radsak, Markus P.; Borg, Irmgard; Buhl, Roland; Schultze-Werninghaus, Gerhard; Taube, Christian
- Abstract
Background: Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) is an activating receptor on inflammatory cells upregulated by microbial products. Elevated levels of sTREM-1 have been associated with the diagnosis and prognosis of patients with sepsis, severe pneumonia and chronic obstructive pulmonary disease (COPD). Objectives: The aim of this study was to define the role of sTREM-1 in acute exacerbations of COPD (AE-COPD) and to investigate the ability of sTREM-1 to differentiate between infectious triggers of AE-COPD. Methods: Smokers without COPD (SM), patients with stable COPD (sCOPD) and patients with AE-COPD were prospectively recruited. sTREM-1 levels were determined by ELISA in serum. Potentially pathogenic bacteria were analyzed by sputum culture, and polymerase chain reaction was used to determine the presence of respiratory viruses. Results: One hundred and ninety-five subjects were included: 64 sCOPD patients, 118 AE-COPD patients and 13 SM. In 62 (52.6%) AE-COPD patients, a respiratory pathogen was detected. Serum levels of sTREM-1 were barely detectable in SM but were significantly increased in patients with sCOPD [97.5 (interquartile value 76.6) pg/ml] and AE-COPD [110.9 (98.5) pg/ml; p < 0.001]. There was no significant difference in sTREM-1 between sCOPD and AE-COPD (p = 0.277). However, in AE-COPD, sTREM-1 was significantly lower in patients with virus detection [87.5 (97.3) pg/ml] compared to those without [120.3 (99.7) pg/ml; p = 0.015]. No difference was found in AE-COPD patients with or without bacterial detection. Conclusions: The present study shows an increase in sTREM-1 in patients with COPD compared to SM but not in AE-COPD compared to sCOPD. Viral exacerbations showed significantly lower sTREM-1 levels than non-viral exacerbations. Copyright © 2011 S. Karger AG, Basel
- Subjects
BACTERIA; BIOMARKERS; CELL receptors; CHI-squared test; STATISTICAL correlation; ENZYME-linked immunosorbent assay; FISHER exact test; INFLAMMATION; LONGITUDINAL method; OBSTRUCTIVE lung diseases; RESEARCH funding; RESPIRATORY syncytial virus; SMOKING; SPUTUM; STATISTICS; U-statistics; DATA analysis; INFLUENZA A virus; DISEASE exacerbation; DATA analysis software; DESCRIPTIVE statistics; BLOOD
- Publication
Respiration, 2012, Vol 83, Issue 2, p133
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000328413