We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Prognostic Value of the Albumin-to-Alkaline Phosphatase Ratio before Chemoradiotherapy in Patients with Nonmetastatic Nasopharyngeal Carcinoma.
- Authors
Yang, Liping; Gao, Jing; Zhou, Yan; Tao, Zhenchao; He, Jian; Yang, Jing; Wang, Ru; Zhang, Yangyang; Huang, Yifan; Zhou, Lingran; Sun, Bin
- Abstract
Introduction: The aim of this study was to evaluate the prognostic value of the albumin-to-alkaline phosphatase ratio (AAPR) in patients with nonmetastatic nasopharyngeal carcinoma (NPC). Methods: Patients with nonmetastatic NPC who underwent chemoradiotherapy (CRT) were retrospectively analyzed. The AAPR was calculated using the last value of albumin to alkaline phosphatase that was measured within 1 week before CRT. The optimal cutoff value for the AAPR value was determined by an X-tile plot. Propensity score matching (PSM) was performed to balance the differences of the baseline characteristics. The Kaplan-Meier method and log-rank test were used to calculate the survival. A Cox proportional hazards regression model was conducted for the multivariate analysis. Results: Totally, 87 patients with nonmetastatic NPC who underwent CRT were included in the analysis. The optimal cutoff level for the AAPR was 0.46. The group with an AAPR ≤0.46 was more likely to have poorer overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) (p = 0.023, p = 0.031 and p = 0.027, for OS, PFS, and DMFS, respectively). In Cox proportional hazards analysis, high AAPR was a better prognostic predictor. Conclusion: AAPR may be a reliable prognostic index for nonmetastatic NPC patients.
- Subjects
NASOPHARYNX cancer; PROGNOSIS; OVERALL survival; PROPORTIONAL hazards models; PROPENSITY score matching
- Publication
Chemotherapy (0009-3157), 2021, Vol 66, Issue 1/2, p40
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000513058