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- Title
A New Perspective on Cardiotoxicity of 5-Fluorouracil.
- Authors
Barutca, Sabri; Ceyhan, Ceyhun; Meydan, Nezih; Ozturk, Banu; Tekten, Tarkan; Onbasili, Alper; Kadikoylu, Gurhan; Bolamanc, Zahit
- Abstract
Background: The pathophysiology of 5-fluorouracil (5-FU) cardiotoxicity is still controversial. The objective of this study was to assess the influence of high-dose leucovorin and infusional 5-FU regimen (HDLV5FU) on cardiac tissues. Methods: We monitored 28 patients (median age 68 years) under HDLV5FU chemotherapy with complete blood counts, cardiac enzymes, C-reactive protein, coagulation tests, Holter electrocardiogram, and conventional echocardiography. Cardiac ultrasonic tissue characterization with integrated backscatter (IBS) analysis was performed in the 16 last enrolled patients. Results: The magnitude of both anterior and posterior cardiac IBS values significantly decreased at the 48th hour of treatment compared to both 0th hour and day 15 (p < 0.003). Cardiac IBS values on the 15th day were not different from the 0th hour. Clinical cardiotoxicity was not observed and other monitored parameters did not change significantly in any patient (p > 0.5 for all). Conclusion: Cardiac IBS analysis suggests that 5-FU might cause reversible subclinical myocardial dysfunction.
- Subjects
FLUOROURACIL; FOLINIC acid; DRUG toxicity; DRUG therapy; PATHOLOGICAL physiology
- Publication
Chemotherapy (0009-3157), 2004, Vol 50, Issue 3, p113
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000077884