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- Title
Making the paper: Todd Golub.
- Abstract
The article presents comments from cancer researcher, Todd Golub, on a paper about interfering with genes that reveal the cause of bone-marrow disorder. Golub stated that the condition, characterized by defective red blood-cell development, severe anaemia and a tendency to progress to acute myeloid leukaemia, had been linked to a gene somewhere in a 1.5-megabase common deleted region on chromosome 5, but they did not have the tools to identify the gene. However, things have changed since there emerged spectacular tools for the procedure such as RNA interference. A particularly persistent postdoc led to the discovery that the 5q-syndrome is caused by a defect in a gene called RPS14, which makes a ribosomal protein.
- Subjects
BONE marrow diseases; GENETIC research; RNA; NUCLEIC acids; RIBOSE; HEMATOPOIETIC system; IMMUNE system; MEDICAL equipment; GOLUB, Todd; RESEARCH personnel
- Publication
Nature, 2008, px
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/7175xa