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- Title
Physical activity predicts reduced plasma β amyloid in the Cardiovascular Health Study.
- Authors
Stillman, Chelsea M.; Lopez, Oscar L.; Becker, James T.; Kuller, Lewis H.; Mehta, Pankaj D.; Tracy, Russell P.; Erickson, Kirk I.
- Abstract
Objective Higher levels of physical activity ( PA) reduce the risk of cognitive impairment, but the underlying mechanisms are unclear. Using longitudinal data from the Cardiovascular Health Study, we examined whether PA predicted plasma A β levels and risk for cognitive decline 9-13 years later. Methods Linear and logistic regressions (controlling for APOE status, age, gender, body mass index, cardiovascular disease, brain white matter lesions, and cystatin C levels) tested associations between PA, A β, and cognitive impairment in a sample of 149 cognitively normal older adults (mean age 83 years). Results More PA at baseline predicted lower levels of A β 9-13 years later. Higher A β levels at year 9 predicted greater risk for cognitive impairment at year 13. Levels of A β at year 9 mediated the relationship between PA and cognitive impairment. Interpretation Greater PA may reduce plasma levels of a neurotoxic peptide at an age when the risk for cognitive impairment is especially high.
- Subjects
PHYSICAL activity; AMYLOID; MILD cognitive impairment; BLOOD serum analysis; OLDER people physiology
- Publication
Annals of Clinical & Translational Neurology, 2017, Vol 4, Issue 5, p284
- ISSN
2328-9503
- Publication type
Article
- DOI
10.1002/acn3.397