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- Title
短链氯化石蜡对褐牙鲆胚胎发育的毒性效应.
- Authors
崔庆奎; 韩典峰; 丁玉竹; 任传博; 张信泽; 赵军强; 崔艳梅; 姜芳; 李佳蔚; 孙琰晴; 王景; 宫向红; 徐英江
- Abstract
Chlorinated paraffins (CPs) are a complex mixture of a series of polychlorinated n-alkanes. Of these, short chain chlorinated paraffins (SCCPs) received a wide interest from domestic and international scholars for their numerous properties as persistent organic pollutants (POPs), but few reports on the toxic effects of SCCPs have been published. In this study, the toxic effects of SCCPs were investigated in Paralichthys olivaceus embryos through 132 h exposure experiment, based on the current status of marine pollution. The results showed that SCCPs had significant embryonic developmental toxicity, including lower embryo-larvae survival with a time-dose effect; a delay in embryo hatching and a decrease in hatching rate at high concentrations (≥1 000 μg·L-1); developmental malformations of embryo-larvae, such as spinal curvature and pericardial edema; and inhibition of larvae growth. In addition, oxidative stress was induced in embryo-larvae by SCCPs exposure. The superoxide dismutase (SOD) activity, catalase activity (CAT) and malondialdehyde (MDA) content were significantly higher (P <0.05) and the relative expression of antioxidant enzyme genes sod and cat were also relatively higher in the experimental group of littermates than in the control group. With the increasing concentration of SCCPs, the SOD and CAT activities of the experimental group were on a decreasing trend, indicating a gradual decrease in the ability to scavenge reactive oxygen radicals. This led to severe lipid peroxidation in the organism, and the MDA content observed in the 10 000 μg·L-1 experimental group of littermates was close to three times that of the control group. The results reveal the ecotoxicity induced by SCCPs on the early developmental stages of marine organisms, which will provide a theoretical basis for the environmental risk assessment of SCCPs.
- Subjects
POISONS; PERSISTENT pollutants; ENVIRONMENTAL risk assessment; CHLORINATED paraffin; MARINE pollution; CAT diseases
- Publication
Asian Journals of Ecotoxicology, 2023, Vol 18, Issue 2, p54
- ISSN
1673-5897
- Publication type
Article
- DOI
10.7524/AJE.1673-5897.20221019001