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- Title
Statins and cerebral hemodynamics.
- Authors
Giannopoulos, Sotirios; Katsanos, Aristeidis H; Tsivgoulis, Georgios; Marshall, Randolph S
- Abstract
HMG-CoA reductase inhibitors (statins) are associated with improved stroke outcome. This observation has been attributed in part to the palliative effect of statins on cerebral hemodynamics and cerebral autoregulation (CA), which are mediated mainly through the upregulation of endothelium nitric oxide synthase (eNOS). Several animal studies indicate that statin pretreatment enhances cerebral blood flow after ischemic stroke, although this finding is not further supported in clinical settings. Cerebral vasomotor reactivity, however, is significantly improved after long-term statin administration in most patients with severe small vessel disease, aneurysmal subarachnoid hemorrhage, or impaired baseline CA.
- Subjects
HEMODYNAMICS; STATINS (Cardiovascular agents); REDUCTASE inhibitors; STROKE treatment; HEALTH outcome assessment; NITRIC oxide synthesis; ENDOTHELIUM; CEREBRAL circulation; CEREBRAL hemorrhage
- Publication
Journal of Cerebral Blood Flow & Metabolism, 2012, Vol 32, Issue 11, p1973
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1038/jcbfm.2012.122