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- Title
Iohexol as a marker of glomerular filtration rate in patients with diabetes: comparison of multiple and simplified sampling protocols.
- Authors
Pucci, L.; Bandinelli, S.; Pilo, M.; Nannipieri, M.; Navalesi, R.; Penno, G.
- Abstract
SUMMARY Aims To report on the reproducibility of iohexol glomerular filtration rate (GFR) estimation, to compare the plasma clearance of iohexol with that of[51Cr]EDTA and to evaluate the reliability of reduced sampling schedules in estimating GFR in Type 1 and Type 2 diabetes mellitus. Methods Agreement was assessed in 15 Type 1 and 26 Type 2 diabetics with creatinine ranging from 53 to 564 μmol/l. Results The regression between multiple-sample iohexol and[51Cr]EDTA clearances was 0.999 in Type 1 and 0.987 in Type 2 diabetes (P < 0.0001 for both). A seven-sample design and the three-sample approach by Brøchner–Mortensen were validated by comparison with the full-sample schedule in 87 patients (51 Type 1, 36 Type 2). Full-sample GFR was 80.3 ± 43.8, seven-sample 79.5 ± 43.9 (r = 0.990) and three-sample 79.8 ± 45.2 ml.min-1.1.73 m-2 (r = 0.972). The coefficients of variation of GFR were 2.7 ± 1.4% and 3.8 ± 1.9% for the full-sample and the seven-sample approaches, respectively, and significantly higher for the three-sample design (6.9 ± 3.4%, P = 0.0001). Conclusions After iohexol injection, the Brøchner–Mortensen schedule does not provide an accurate estimate of GFR. The seven-sample approach gives acceptable errors and allows a good estimate of GFR throughout a wide range of renal function.
- Subjects
GLOMERULAR filtration rate; ETHYLENEDIAMINETETRAACETIC acid; DIABETES
- Publication
Diabetic Medicine, 2001, Vol 18, Issue 2, p116
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1046/j.1464-5491.2001.00404.x