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- Title
Antioxidant Consumption is Associated with Decreased Odds of Congenital Limb Deficiencies.
- Authors
Pace, Nelson D.; Desrosiers, Tania A.; Carmichael, Suzan L.; Shaw, Gary M.; Olshan, Andrew F.; Siega‐Riz, Anna Maria; the National Birth Defects Prevention Study; Siega-Riz, Anna Maria; National Birth Defects Prevention Study
- Abstract
<bold>Background: </bold>Approximately 1 in 2000 infants is born with a limb deficiency in the US. Research has shown that women's periconceptional diet and use of vitamin supplements can affect risk of birth defects. We investigated whether maternal consumption of nutritional antioxidants was associated with occurrence of transverse limb deficiency (TLD) and longitudinal limb deficiencies (LLD).<bold>Methods: </bold>We analysed case-control data from mothers and their singleton infants with TLD (n = 566), LLD (n = 339), or no malformation (controls; n = 9384) in the National Birth Defects Prevention Study (1997-2009). Using a modified food frequency, we estimated usual pre-pregnancy antioxidant consumption by total fruit and vegetable consumption (in grams) grouped into tertiles, and cumulative antioxidant score (ranging from 1 to 10) based on consumption of three antioxidants: beta-carotene, lycopene, and lutein. We estimated odds ratios (OR) adjusted for maternal age, race/ethnicity, education, smoking, alcohol use, body mass index, and total energy.<bold>Results: </bold>Compared to women in the lowest tertile of fruit and vegetable consumption, women in the highest tertile were less likely to have infants with TLD (OR 0.74, 95% CI 0.57, 0.96) or LLD (OR 0.82, 95% CI 0.59, 1.13). Compared to the lowest antioxidant consumption score of 1, those with the highest score of 10 had ORs of 0.68 (95% CI 0.48, 0.95) for TLD and 0.77 (95% CI 0.50, 1.17) for LLD.<bold>Conclusions: </bold>Dietary intake of antioxidants was associated with reduced odds of limb deficiencies. These findings add further evidence for women's periconceptional diet reducing occurrence of some birth defects.
- Subjects
HUMAN abnormalities; EXTREMITIES (Anatomy); ANTIOXIDANTS; PATHOLOGY; ANATOMY; CAROTENOIDS; COMPARATIVE studies; ALCOHOL drinking; INTERVIEWING; MATERNAL age; RESEARCH methodology; MEDICAL cooperation; POPULATION; RESEARCH; SMOKING; EVALUATION research; EDUCATIONAL attainment; BODY mass index; CASE-control method; BETA carotene; ABNORMALITIES in the anatomical extremities; LUTEIN; GENETICS
- Publication
Paediatric & Perinatal Epidemiology, 2018, Vol 32, Issue 1, p90
- ISSN
0269-5022
- Publication type
journal article
- DOI
10.1111/ppe.12403