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- Title
Improved Delivery in Cell Culture of Radiolabeled Antisense DNAs by Duplex Formation.
- Authors
Xinrong Liu; Kayoko Nakamura; Yi Wang; Surong Zhang; Jiang He; Guozheng Liu; Shuping Dou; Atsushi Kubo; Mary Rusckowski; Donald Hnatowich
- Abstract
<span class="AbstractHeading">Abstract</span><div class="AbstractSection"><div class=""><span class="AbstractSectionHeading"><a name="ASec1"></a>Purpose </span>Delivery remains an unresolved problem in applications requiring intravenous administration of DNAs. Recently improved antisense translation interruption in cells was reported for an antisense (AS) oligomer as a duplex compared to singlet AS oligomer presumably because of improved delivery. The unstable phosphodiester backbone of the sense (S) oligomer and its shorter chain length apparently encouraged intracellular dissociation and release of the AS oligomer. We have investigated the mechanism involved to evaluate whether the approach may be useful for antisense radionuclide imaging.
- Subjects
DNA; OLIGOMERS; POLYMERS; RADIONUCLIDE imaging; PHOSPHODIESTERS
- Publication
Molecular Imaging & Biology, 2006, Vol 8, Issue 5, p278
- ISSN
1536-1632
- Publication type
Article
- DOI
10.1007/s11307-006-0050-7