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- Title
33-year follow-up after valvular surgery for carcinoid heart disease.
- Authors
Bergsten, Johannes; Flachskampf, Frank A; Lundin, Lennart; Öhagen, Patrik; Albåge, Anders
- Abstract
Aims Valvular surgery has improved long-term prognosis in severe carcinoid heart disease (CaHD). Experience is limited and uncertainty remains about predictors for survival and strategy regarding single vs. double-valve surgery. The aim was to review survival and echocardiographic findings after valvular surgery for CaHD at our institution. Methods and results Between 1986 and 2019, 60 consecutive patients, median age 64 years, underwent valve surgery for severe CaHD. Operations involved combined tricuspid valve replacement (TVR) and pulmonary valve replacement (PVR) in 42 cases, and TVR-only or TVR with pulmonary valvotomy (no PVR) in 18 patients. All implanted valves were bioprosthetic. Preoperative echocardiography, creatinine, NT-pro-brain natriuretic peptide (NT-pro-BNP), and 24-h urinary 5-hydroxyindoleacetic acid (5-HIAA) were obtained. 30-Day mortality was 12% (n =7), and 8% for the most recent decade 2010–2019. Median survival was 2.2 years and maximum survival 21 years. Patients undergoing combined TVR and PVR had significantly higher survival compared with operations without PVR (median 3.0 vs. 0.9 years, P = 0.02). Preoperative levels of NT-pro-BNP and 5-HIAA in the top quartile predicted poor survival. On preoperative echocardiograms, pulmonary regurgitation was severe in 51% and indeterminate in 17%. Postoperative echocardiography confirmed relatively good durability of bioprostheses, relative to the patients' limited oncological life expectancy. Conclusion Valvular surgery in CaHD has an acceptable perioperative risk. Survival for combined TVR and PVR was significantly higher compared with operations without PVR. Bioprosthetic valve replacement appears to have adequate durability. Preoperative echocardiography may underestimate pulmonary pathology. Combined TVR and PVR should be considered in most patients.
- Subjects
SURGICAL complication risk factors; HEART disease prognosis; HEART disease related mortality; PATIENT aftercare; ECHOCARDIOGRAPHY; INDOLE compounds; TIME; PREOPERATIVE period; RETROSPECTIVE studies; BIOPROSTHETIC heart valves; TREATMENT effectiveness; DESCRIPTIVE statistics; PEPTIDE hormones; HEART diseases; CREATININE; EVALUATION
- Publication
European Heart Journal - Cardiovascular Imaging, 2022, Vol 23, Issue 4, p524
- ISSN
2047-2404
- Publication type
Article
- DOI
10.1093/ehjci/jeab049