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Bringing Geroscience into the Mainstream: From Education to Clinical Practice, What Will It Take?
Published in:
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2024, v. 79, n. 9, p. 1, doi. 10.1093/gerona/glae020
By:
- Al-Naggar, Iman M;
- Campellone, Kenneth G;
- Espinoza, Sara E;
- Justice, Jamie N;
- Orr, Miranda E;
- Kozikowski, Chester;
- van der Willik, Odette;
- Thatcher, Christine;
- Schmader, Kenneth;
- Pignolo, Robert J;
- Newman, John C;
- Kuchel, George A
Publication type:
Article
Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling.
Published in:
Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01324-9
By:
- Walker, Jamie M.;
- Kazempour Dehkordi, Shiva;
- Fracassi, Anna;
- Vanschoiack, Alison;
- Pavenko, Anna;
- Taglialatela, Giulio;
- Woltjer, Randall;
- Richardson, Timothy E.;
- Zare, Habil;
- Orr, Miranda E.
Publication type:
Article
Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [<sup>11</sup>C]MPC‐6827 PET imaging in rodent models of Alzheimer's‐related pathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 9, p. 6082, doi. 10.1002/alz.14083
By:
- Damuka, Naresh;
- Irmen, Riley E.;
- Krizan, Ivan;
- Miller, Mack;
- Gollapelli, Krishna K.;
- Bhoopal, Bhuvanachandra;
- Deep, Ojasvi;
- Bansode, Avinash;
- Lockhart, Samuel N.;
- Orr, Miranda E.;
- Jadiya, Pooja;
- Bashetti, Nagaraju;
- Kumar, J. V. Shanmukha;
- Mintz, Akiva;
- Whitlow, Christopher T.;
- Craft, Suzanne;
- Macauley, Shannon L.;
- Solingapuram Sai, Kiran K.
Publication type:
Article
Spatial proteomics of hippocampal subfield‐specific pathology in Alzheimer's disease and primary age‐related tauopathy.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 2, p. 783, doi. 10.1002/alz.13484
By:
- Walker, Jamie M.;
- Orr, Miranda E.;
- Orr, Timothy C.;
- Thorn, Emma L.;
- Christie, Thomas D.;
- Yokoda, Raquel T.;
- Vij, Meenakshi;
- Ehrenberg, Alexander J.;
- Marx, Gabriel A.;
- McKenzie, Andrew T.;
- Kauffman, Justin;
- Selmanovic, Enna;
- Wisniewski, Thomas;
- Drummond, Eleanor;
- White, Charles L.;
- Crary, John F.;
- Farrell, Kurt;
- Kautz, Tiffany F.;
- Daoud, Elena V.;
- Richardson, Timothy E.
Publication type:
Article
Investigating neuronal senescence marker, p19<sup>INK4d</sup>, in mouse and human brains.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082962
By:
- Hudson, Hannah R.;
- Orr, Timothy C.;
- Orr, Miranda E.
Publication type:
Article
Exploration of the tumorigenic, metabolic, and cognitive consequences of tau protein removal.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073069
By:
- Erichsen, Jennifer M.;
- Garbarino, Valentina R.;
- Rodriguez, Anna;
- Lee, Jillian K.;
- Shayne, Justin C.;
- Orr, Timothy C.;
- Orr, Miranda E.
Publication type:
Article
Hippocampal subregion‐specific proteomic differences between Alzheimer disease (AD) and primary age‐related tauopathy (PART).
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073721
By:
- Walker, Jamie M.;
- Orr, Miranda E.;
- Orr, Timothy C.;
- Crary, John F.;
- Woodoff‐Leith, Emma;
- Teixeira‐Yokoda, Raquel;
- Gupta, Meenakshi;
- Daoud, Elena;
- Kautz, Tiffany F;
- Richardson, Timothy E.
Publication type:
Article
Hippocampal subregion‐specific proteomic differences between Alzheimer disease (AD) and primary age‐related tauopathy (PART).
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073721
By:
- Walker, Jamie M.;
- Orr, Miranda E.;
- Orr, Timothy C.;
- Crary, John F.;
- Woodoff‐Leith, Emma;
- Teixeira‐Yokoda, Raquel;
- Gupta, Meenakshi;
- Daoud, Elena;
- Kautz, Tiffany F;
- Richardson, Timothy E.
Publication type:
Article
Cellular senescence profiling reveals distinct sub‐types of neurofibrillary tangle bearing neurons.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.069118
By:
- Orr, Miranda E;
- Orr, Timothy C;
- Dehkordi, Shiva Kazempour;
- Zare, Habil;
- Walker, Jamie M.;
- Keene, C Dirk
Publication type:
Article
Initial biological evaluations of a novel microtubule‐based PET ligand in Alzheimer’s disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.054207
By:
- Damuka, Naresh;
- Orr, Miranda E.;
- Macauley, Shannon L.;
- Shively, Carol A.;
- Lockhart, Samuel N.;
- Bansode, Avinash;
- Kim, Jeongchul;
- Frye, Brett M.;
- Register, Thomas C.;
- Mintz, Akiva;
- Whitlow, Christopher T.;
- Craft, Suzanne;
- Solingapuram Sai, Kiran K.
Publication type:
Article
Initial biological evaluation of a novel microtubule‐based PET ligand in rodent and NHP models of AD.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.052101
By:
- Damuka, Naresh;
- Macauley, Shannon L.;
- Orr, Miranda E.;
- Shively, Carol A.;
- Lockhart, Samuel N.;
- Bansode, Avinash;
- Frye, Brett M.;
- Mintz, Akiva;
- Kim, Jeongchul;
- Register, Thomas C.;
- Whitlow, Christopher T.;
- Craft, Suzanne;
- Solingapuram Sai, Kiran K.
Publication type:
Article
A head‐to‐head comparison between senolytic therapies, dasatinib plus quercetin and fisetin, indicates sex‐ and genotype‐specific differences in translationally relevant outcomes: Developing topics.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047607
By:
- Garbarino, Valentina R;
- Tran, Sydney;
- Glassman, Jordan E;
- Kirkland, James L;
- Musi, Nicolas;
- Seshadri, Sudha;
- Orr, Miranda E
Publication type:
Article
Differential protein expression identified by digital spatial profiling (DSP) in the hippocampi of resilient individuals: Human neuropathology: AD neuropathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.046444
By:
- Walker, Jamie M.;
- Dehkordi, Shiva Kazempour;
- Richardson, Timothy;
- Zare, Habil;
- Orr, Miranda E.
Publication type:
Article
Results from a pilot study: The effects of nicotinamide riboside on mild cognitive impairment: Human/Human trials: Nutraceuticals and non‐pharmacological interventions.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.044746
By:
- Orr, Miranda E.;
- Kotkowski, Eithan;
- Bair‐Kelps, Darcy;
- Romo, Terry;
- Espinoza, Sara;
- Musi, Nicolas;
- Powers, Becky
Publication type:
Article
The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration.
Published in:
Life (2075-1729), 2021, v. 11, n. 3, p. 229, doi. 10.3390/life11030229
By:
- Sah, Eric;
- Krishnamurthy, Sudarshan;
- Ahmidouch, Mohamed Y.;
- Gillispie, Gregory J.;
- Milligan, Carol;
- Orr, Miranda E.;
- Riessland, Markus
Publication type:
Article
Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells—Implications for Cancer and Neurodegeneration.
Published in:
Life (2075-1729), 2021, v. 11, n. 2, p. 153, doi. 10.3390/life11020153
By:
- Gillispie, Gregory J.;
- Sah, Eric;
- Krishnamurthy, Sudarshan;
- Ahmidouch, Mohamed Y.;
- Zhang, Bin;
- Orr, Miranda E.;
- Riessland, Markus
Publication type:
Article
TAU AGGREGATION INDUCES CELLULAR SENESCENCE IN THE BRAIN.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P679, doi. 10.1016/j.jalz.2017.06.842
By:
- Orr, Miranda E.;
- Carlson, George A.;
- Musi, Nicolas
Publication type:
Article
P1-095: CNS stem cell lines from tau transgenic mice as models for frontotemporal dementia
Published in:
2008
By:
- Orr, Miranda E.;
- Giri, Ranjit K.;
- Ashe, Karen H.;
- Carlson, George A.
Publication type:
Abstract
Genotype-Specific Differences between Mouse CNS Stem Cell Lines Expressing Frontotemporal Dementia Mutant or Wild Type Human Tau.
Published in:
PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0039328
By:
- Orr, Miranda E.;
- Pitstick, Rose;
- Canine, Brenda;
- Ashe, Karen H.;
- Carlson, George A.
Publication type:
Article
45 Senolytic Therapy Transiently Reduces Inflammatory Markers in Primary Blood Mononuclear Cells of Individuals with Early Alzheimer's Disease: Exploring the Conserved Transcriptional Response to Adversity as a Biomarker for Disease State.
Published in:
2023
By:
- Garbarino, Valentina R.;
- Xu, Peng;
- Zhang, Bin;
- Biggs, Glenn;
- Gonzales, Mitzi M.;
- Orr, Miranda E.
Publication type:
Abstract
Aging‐related Alzheimer's disease‐like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus).
Published in:
American Journal of Primatology, 2021, v. 83, n. 11, p. 1, doi. 10.1002/ajp.23260
By:
- Frye, Brett M.;
- Craft, Suzanne;
- Latimer, Caitlin S.;
- Keene, C. Dirk;
- Montine, Thomas J.;
- Register, Thomas C.;
- Orr, Miranda E.;
- Kavanagh, Kylie;
- Macauley, Shannon L.;
- Shively, Carol A.
Publication type:
Article
A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment.
Published in:
GeroScience, 2024, v. 46, n. 1, p. 665, doi. 10.1007/s11357-023-00999-9
By:
- Orr, Miranda E.;
- Kotkowski, Eithan;
- Ramirez, Paulino;
- Bair-Kelps, Darcy;
- Liu, Qianqian;
- Brenner, Charles;
- Schmidt, Mark S.;
- Fox, Peter T.;
- Larbi, Anis;
- Tan, Crystal;
- Wong, Glenn;
- Gelfond, Jonathan;
- Frost, Bess;
- Espinoza, Sara;
- Musi, Nicolas;
- Powers, Becky
Publication type:
Article
Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model.
Published in:
EJNMMI Research, 2022, v. 12, n. 1, p. 1, doi. 10.1186/s13550-022-00912-z
By:
- Damuka, Naresh;
- Orr, Miranda E.;
- Bansode, Avinash H.;
- Krizan, Ivan;
- Miller, Mack;
- Lee, Jillian;
- Macauley, Shannon L.;
- Whitlow, Christopher T.;
- Mintz, Akiva;
- Craft, Suzanne;
- Solingapuram Sai, Kiran Kumar
Publication type:
Article
Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain.
Published in:
Frontiers in Neuroscience, 2016, v. 10, p. 1, doi. 10.3389/fnins.2016.00504
By:
- Orr, Miranda E.;
- Garbarino, Valentina R.;
- Salinas, Angelica;
- Buffenstein, Rochelle;
- Sallet, Jérôme;
- Cozzi, Bruno
Publication type:
Article
Can oral health and oral‐derived biospecimens predict progression of dementia?
Published in:
Oral Diseases, 2020, v. 26, n. 2, p. 249, doi. 10.1111/odi.13201
By:
- Orr, Miranda E.;
- Reveles, Kelly R.;
- Yeh, Chih‐Ko;
- Young, Eric H.;
- Han, Xianlin
Publication type:
Article
Tau protein aggregation is associated with cellular senescence in the brain.
Published in:
Aging Cell, 2018, v. 17, n. 6, p. N.PAG, doi. 10.1111/acel.12840
By:
- Musi, Nicolas;
- Valentine, Joseph M.;
- Sickora, Kathryn R.;
- Baeuerle, Eric;
- Thompson, Cody S.;
- Shen, Qiang;
- Orr, Miranda E.
Publication type:
Article
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application.
Published in:
Molecular Neurodegeneration, 2022, v. 17, n. 1, p. 1, doi. 10.1186/s13024-022-00517-z
By:
- Wang, Minghui;
- Song, Won-min;
- Ming, Chen;
- Wang, Qian;
- Zhou, Xianxiao;
- Xu, Peng;
- Krek, Azra;
- Yoon, Yonejung;
- Ho, Lap;
- Orr, Miranda E.;
- Yuan, Guo-Cheng;
- Zhang, Bin
Publication type:
Article
The landscape of human tissue and cell type specific expression and co-regulation of senescence genes.
Published in:
Molecular Neurodegeneration, 2022, v. 17, n. 1, p. 1, doi. 10.1186/s13024-021-00507-7
By:
- Xu, Peng;
- Wang, Minghui;
- Song, Won-min;
- Wang, Qian;
- Yuan, Guo-Cheng;
- Sudmant, Peter H.;
- Zare, Habil;
- Tu, Zhidong;
- Orr, Miranda E.;
- Zhang, Bin
Publication type:
Article
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application.
Published in:
Molecular Neurodegeneration, 2021, v. 17, n. 1, p. 1, doi. 10.1186/s13024-022-00517-z
By:
- Wang, Minghui;
- Song, Won-min;
- Ming, Chen;
- Wang, Qian;
- Zhou, Xianxiao;
- Xu, Peng;
- Krek, Azra;
- Yoon, Yonejung;
- Ho, Lap;
- Orr, Miranda E.;
- Yuan, Guo-Cheng;
- Zhang, Bin
Publication type:
Article
753-P: Senolytics Improve Diabetes Measures in Type 2 Diabetic Nonhuman Primates: A Pilot Study.
Published in:
Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-753-P
By:
- RUGGIERO, ALISTAIRE D.;
- BLOCK, MASHA;
- DAVIS, MATTHEW;
- VEMURI, RAVICHANDRA;
- ORR, MIRANDA E.;
- KAVANAGH, KYLIE
Publication type:
Article

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