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- Title
A Comparison of Buprenorphine + Naloxone to Buprenorphine and Methadone in the Treatment of Opioid Dependence during Pregnancy: Maternal and Neonatal Outcomes.
- Authors
Lund, Ingunn O.; Fischer, Gabriele; Welle-Strand, Gabrielle K.; OGrady, Kevin E.; Debelak, Kimber; Morrone, William R.; Jones, Hendre E.
- Abstract
Given that buprenorphine + naloxone is prescribed for opioid-dependent pregnant women, it is important to examine the extent to which it differs from buprenorphine alone, methadone, or methadone-assisted withdrawal on neonatal and maternal outcomes. Summary statistics on maternal and neonatal outcomes were collected from 7 previously published studies examining treatment for opioid-dependent pregnant women that represented a range of research methodologies. Outcomes from these studies were compared to the same outcomes for 10 women treated with the combined buprenorphine + naloxone product. There were no significant differences in maternal outcomes for buprenorphine + naloxone compared to buprenorphine, methadone, or methadone-assisted withdrawal. Preliminary findings suggest no significant adverse maternal or neonatal outcomes related to the use of buprenorphine + naloxone for the treatment of opioid dependence during pregnancy. However, further research should examine possible differences between buprenorphine + naloxone and buprenorphine alone or methadone in fetal physical development.
- Subjects
METHADONE treatment programs; BUPRENORPHINE; NALOXONE; COMBINATION drug therapy; CHILDREN of prenatal substance abuse; EVALUATION of medical care; PREGNANCY; PREGNANCY complications; SUBSTANCE abuse in pregnancy; SYSTEMATIC reviews; NEONATAL abstinence syndrome; PRENATAL exposure delayed effects; THERAPEUTICS
- Publication
Substance Abuse: Research & Treatment, 2013, Issue 7, p61
- ISSN
1178-2218
- Publication type
Article
- DOI
10.4137/SART.S10955