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- Title
Genetic and Phenotypic Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Isolates from a Tertiary Hospital in Beijing.
- Authors
Ni, Qin; Yao, Xingwei; Li, Jinhui; Ma, Jinghan; Wang, Kaiying; Liu, Xiong; Li, Peihan; Yang, Lang; Li, Peng; Li, Shenlong
- Abstract
aimed to study the phenotypic and genotypic characteristics of carbapenem-resistant K. pneumoniae (CRKP) isolates from a hospital in Beijing. Methods: Twenty-four CRKP clinical isolates were collected within a half-year to investigate antimicrobial resistance and genomic characteristics. Illumina and Nanopore sequencing were performed to assemble and annotate genomes. Results: All strains were multi-drug resistant. Twenty-two strains carried the blaKPC-2 gene and two harbored blaNDM-5. Multilocus sequence type(MLST) analysis identified five sequence types; most isolates belonged to ST11. Three strains were isolated from the same patient; each carried a different plasmid replicon, either IncFII (pHN7A8), IncX, or IncFIB (K). Conclusion: This study furthers the understanding of CRKP antimicrobial resistance genotypes, and may facilitate the control of nosocomial infections caused by antimicrobial-resistant pathogens.
- Subjects
BEIJING (China); CARBAPENEM-resistant bacteria; KLEBSIELLA pneumoniae; PHENOTYPES; DRUG resistance in microorganisms; NOSOCOMIAL infections
- Publication
Infection & Drug Resistance, 2022, Vol 15, p7503
- ISSN
1178-6973
- Publication type
Article
- DOI
10.2147/IDR.S395920