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- Title
Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1.
- Authors
S�uczanowska-G��bowsk, Sylwia; Laszczy�ska, Maria; Piotrowska, Katarzyna; G��bowski, Wojciech; Kopchick, John J; Bartke, Andrzej; Kucia, Magda; Ratajczak, Mariusz Z
- Abstract
Background: It is well known that somatotrophic/insulin signaling affects lifespan in experimental animals, and one of the signs of aging is progressive gonadal dysfunction.Methods: To study the effects of insulin-like growth factor-1 (IGF-1) plasma level on ovaries, we analyzed ovaries isolated from 2-year-old growth hormone receptor knockout (GHR-KO) Laron dwarf mice, with low circulating plasma levels of IGF-1, and 6-month-old bovine growth hormone transgenic (bGHTg) mice, with high circulating plasma levels of IGF-1. The ages of the Laron dwarf mutants employed in our studies were selected based on their overall survival (up to ~ 4 years for Laron dwarf mice and ~ 1 year for bGHTg mice). Results: Morphological analysis of the ovaries of mice that reached ~50% of their maximal life span revealed a lower biological age for the ovaries isolated from 2-year-old Laron dwarf mice than their normal-lifespan wild type littermates. By contrast, the ovarian morphology of increased in size 6 month old bGHTg mice was generally normal. Conclusion: Ovaries isolated from 2-year-old Laron dwarf mice exhibit a lower biological age compared with ovaries from normal WT littermates at the same age. At the same time, no morphological features of accelerated aging were found in 0.5-year-old bGHTg mice compared with ovaries from normal the same age-matched WT littermates.
- Subjects
OVARIES; LARON dwarfism; MORPHOLOGY; BLOOD plasma; TRANSGENIC mice; INSULIN
- Publication
Journal of Ovarian Research, 2012, Vol 5, Issue 1, p18
- ISSN
1757-2215
- Publication type
Article
- DOI
10.1186/1757-2215-5-18