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- Title
CD81 Expression in the Differential Diagnosis of Chronic Lymphocytic Leukemia.
- Authors
Afacan-Öztürk, Hacer B.; Falay, Mesude; Albayrak, Murat; Yıldız, Abdulkerim; Öztürk, Ҫiğdem Pala; Maral, Senem; Özet, Gülsüm
- Abstract
Background: Immunophenotyping has a central role in CLL. However, CLL is a very heterogenous disease, both morphologically and immunophenotypically; thus, its diagnosis may prove a challenge. We investigated CD81 expression in the differential diagnosis of CLL and MCL. Methods: We retrospectively examined CD81 expression with 8 color Multiparameter Flow cytometry devices in 101 CLL and 19 MCL cases. Results: We found negative CD81 expression in CLL cases whereas it was positive in MCL cases. Conclusions: Our results suggest that CD81 may be a valuable marker for the differential diagnosis of CLL. We are of the opinion that it should be definitely included in the diagnostic algorithm for CLL.
- Subjects
CHRONIC lymphocytic leukemia; CD18 antigen; IMMUNOPHENOTYPING; GENE expression; FLOW cytometry
- Publication
Clinical Laboratory, 2019, Vol 65, p313
- ISSN
1433-6510
- Publication type
Article
- DOI
10.7754/Clin.Lab.2018.180802