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- Title
The effect of etanercept on a case of amyloidosis secondary to ankylosing spondylitis: results of 2-year follow-up.
- Authors
Yilmaz, Halim; Kocabas, Hilal; Erkin, Gulten
- Abstract
Secondary amyloidosis (type AA) is rarely encountered but can be a significant complication of ankylosing spondylitis (AS) and may lead to proteinuria and renal dysfunction. Anti-tumor necrosis factor-alpha (anti-TNF-α) agents may be used to induce clinical remission by suppressing systemic inflammation in secondary amyloidosis. The patient described , with the diagnosis of AS, was diagnosed with secondary amyloidosis, despite treatment with disease modifying anti-rheumatic medication. He developed marked proteinuria, renal dysfunction and low levels of serum albumin. Diagnosis of amyloidosis was confirmed by renal biopsy. During a 2-year treatment period with etanercept, an anti-TNF-α agent, a definite improvement was determined in all parameters. This case illustrates that in the treatment of secondary amyloidosis related to AS, etanercept, an anti-TNF-α agent, can be considered an effective therapeutic option.
- Subjects
ETANERCEPT; AMYLOIDOSIS treatment; ANKYLOSING spondylitis; PROTEINURIA; KIDNEY diseases; SERUM albumin; FOLLOW-up studies (Medicine); THERAPEUTICS
- Publication
Acta Reumatológica Portuguesa, 2013, Vol 38, Issue 4, p299
- ISSN
0303-464X
- Publication type
Article