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- Title
Adaptive Amphiphilic Dendrimer-Based Nanoassemblies as Robust and Versatile siRNA Delivery Systems.
- Authors
Liu, Xiaoxuan; Zhou, Jiehua; Yu, Tianzhu; Chen, Chao; Cheng, Qiang; Sengupta, Kheya; Huang, Yuanyu; Li, Haitang; Liu, Cheng; Wang, Yang; Posocco, Paola; Wang, Menghua; Cui, Qi; Giorgio, Suzanne; Fermeglia, Maurizio; Qu, Fanqi; Pricl, Sabrina; Shi, Yanhong; Liang, Zicai; Rocchi, Palma
- Abstract
siRNA delivery remains a major challenge in RNAi-based therapy. Here, we report for the first time that an amphiphilic dendrimer is able to self-assemble into adaptive supramolecular assemblies upon interaction with siRNA, and effectively delivers siRNAs to various cell lines, including human primary and stem cells, thereby outperforming the currently available nonviral vectors. In addition, this amphiphilic dendrimer is able to harness the advantageous features of both polymer and lipid vectors and hence promotes effective siRNA delivery. Our study demonstrates for the first time that dendrimer-based adaptive supramolecular assemblies represent novel and versatile means for functional siRNA delivery, heralding a new age of dendrimer-based self-assembled drug delivery in biomedical applications.
- Subjects
AMPHIPHILES; DENDRIMERS; SMALL interfering RNA; SUPRAMOLECULAR chemistry; STEM cells
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 44, p11822
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201406764