We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Rhodium(III)-Catalyzed CC and CO Coupling of Quinoline N-Oxides with Alkynes: Combination of CH Activation with O-Atom Transfer.
- Authors
Zhang, Xueyun; Qi, Zisong; Li, Xingwei
- Abstract
[Cp*RhIII]-catalyzed CH activation of arenes assisted by an oxidizing NO or NN directing group has allowed the construction of a number of hetercycles. In contrast, a polar NO bond is well-known to undergo O-atom transfer (OAT) to alkynes. Despite the liability of NO bonds in both CH activation and OAT, these two important areas evolved separately. In this report, [Cp*RhIII] catalysts integrate both areas in an efficient redox-neutral coupling of quinoline N-oxides with alkynes to afford α-(8-quinolyl)acetophenones. In this process the NO bond acts as both a directing group for CH activation and as an O-atom donor.
- Subjects
ALKYNES; HETEROCYCLIC compounds; OXIDES; RHODIUM catalysts; AROMATIC compound synthesis
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 40, p10794
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201406747