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- Title
Functional involvement of cerebral cortex in Duchenne muscular dystrophy.
- Authors
Di Lazzaro, Vincenzo; Restuccia, Domenico; Servidei, Serenella; Nardone, Raffaele; Oliviero, Antonio; Profice, Paolo; Mangiola, Fortunato; Tonali, Pietro; Rothwell, John C.; Di Lazzaro, V; Restuccia, D; Servidei, S; Nardone, R; Oliviero, A; Profice, P; Mangiola, F; Tonali, P; Rothwell, J C
- Abstract
Transcranial stimulation was performed in 4 patients with Duchenne muscular dystrophy and 4 control subjects. The patients' central motor conduction time was normal. The threshold for evoking electromyographic responses using electrical anodal stimulation was the same in both groups, but the threshold for stimulation with a circular magnetic coil at the vertex was higher in the patients. This is compatible with reduced cortical excitability that may be related to the deficiency of brain synaptic dystrophin.
- Subjects
CEREBRAL cortex; COMPARATIVE studies; ELECTRIC stimulation; ELECTROMYOGRAPHY; MAGNETICS; RESEARCH methodology; MEDICAL cooperation; MUSCULAR dystrophy; NEURAL conduction; SENSORY perception; RESEARCH; RESEARCH funding; EVALUATION research; NEURAL pathways
- Publication
Muscle & Nerve, 1998, Vol 21, Issue 5, p662
- ISSN
0148-639X
- Publication type
journal article
- DOI
10.1002/(SICI)1097-4598(199805)21:5<662::AID-MUS18>3.0.CO;2-X