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- Title
Malignant histiocytosis with rearrangement of the heavy chain gene and evidence of monocyte-macrophage lineage.
- Authors
Kamesaki, Hiroshi; Koya, Mitsuhiko; Miwa, Hiroshi; Kita, Kenkichi; Doi, Shoichi; Tatsumi, Eiji; Hatanaka, Masakazu; Uchino, Haruto; Kamesaki, H; Koya, M; Miwa, H; Kita, K; Doi, S; Tatsumi, E; Hatanaka, M; Uchino, H
- Abstract
A unique case of malignant histiocytosis (MH) is reported. Its origin from the monocyte-macrophage system was indicated by expression of highly specific myeloid cell markers (My4, MCS2, and cytoplasmic lysozyme), diffuse activity of acid phosphatase and NaF-sensitive alpha-naphthyl acetate esterase, lack of immunologic markers specific for other cell lineages, and germ line configuration of the immunoglobulin light chain gene and the T-cell receptor beta-chain gene. Its neoplastic nature was suggested by the single rearranged band of the immunoglobulin heavy chain gene.
- Publication
Cancer (0008543X), 1988, Vol 62, Issue 7, p1306
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19881001)62:7<1306::AID-CNCR2820620711>3.0.CO;2-U