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- Title
A case report of T-cell lymphoma with suppressor phenotype and helper function for immunoglobulin synthesis.
- Authors
Oshimi, Kazuo; Aoyama, Masako; Ohtani, Toshika; Okawa, Hiroji; Yata, Junichi; Watanabe, Shaw; Mizoguchi, Hideaki; Oshimi, K; Aoyama, M; Ohtani, T; Okawa, H; Yata, J; Watanabe, S; Mizoguchi, H
- Abstract
A patient with T-cell lymphoma is presented. The morphologic features of a biopsied lymph node were consistent with adult T-cell lymphoma with hypergammaglobulinemia, and most of the lymph node cells were reactive with monoclonal antibody OKT8, which detects suppressor/cytotoxic T lymphocytes. However, in a pokeweed mitogen-driven test system in which the capability of T lymphocytes to help or suppress the differentiation of B lymphocytes is measured, the lymphoma cells induced immunoglobulin synthesis of B lymphocytes, thus providing helper function. As far as we know, this is the first report on T-cell lymphoma having suppressor phenotype and helper function for immunoglobulin synthesis.
- Publication
Cancer (0008543X), 1984, Vol 54, Issue 9, p2029
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19841101)54:9<2029::AID-CNCR2820540941>3.0.CO;2-L