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- Title
The roles of staging laparotomy, chemotherapy, and radiotherapy in the management of localized diffuse large cell lymphoma: a study of 75 patients.
- Authors
Lester, Joel N.; Fuller, Lillian M.; Conrad, Fred G.; Sullivan, Jane A.; Velasquez, William S.; Butler, James J.; Shullenberger, C. C.; Lester, J N; Fuller, L M; Conrad, F G; Sullivan, J A; Velasquez, W S; Butler, J J
- Abstract
A retrospective study of 75 laparotomy-studied Stage I and II patients with diffuse large cell (histiocytic) lymphoma was conducted to determine the relative contributions of laparotomy, radiotherapy, and combination chemotherapy to their management. The treatment programs were radiotherapy alone, radiotherapy followed by adjuvant chemotherapy, and alternating chemotherapy-radiotherapy. Treatment selection was based on disease presentation, with limited therapy used for favorable patterns and intensive therapy used in prognostically unfavorable settings. Disease-free survival was best in those treated with initial chemotherapy, even though these patients comprised the least favorable prognostic group. A select subset of patients, those with extranodal head and neck disease, obtained good results with radiotherapy alone, but for other presentations this was not a successful approach. Differences in results for the three treatment programs are discussed in relation to future treatment decisions.
- Subjects
THERAPEUTIC use of antineoplastic agents; HEAD tumors; COMBINATION drug therapy; B cell lymphoma; RETROSPECTIVE studies; PROGNOSIS; CANCER relapse; TUMOR classification; ABDOMINAL tumors; ABDOMINAL surgery; RADIATION doses; NECK tumors
- Publication
Cancer (0008543X), 1982, Vol 49, Issue 9, p1746
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19820501)49:9<1746::AID-CNCR2820490903>3.0.CO;2-M