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- Title
The effect of photon irradiation on blood-brain barrier permeability to methotrexate in mice.
- Authors
Griffin, Thomas W.; Rasey, Janet S.; Bleyer, W. Archie; Griffin, T W; Rasey, J S; Bleyer, W A
- Abstract
Methotrexate was administered by intraperitoneal injection (100 mg/kg) to unirradiated mice, and to mice receiving varying doses of cranial irradiation. The animals were sacrificed 24 hours after injection, and methotrexate assays were performed on brain tissue. No methotrexate was detected in the brains of the unirradiated animals. Detectable levels of methotrexate were present after 2000 rad cranial irradiation, but not after 500 rad, 1000 rad, or 1500 rad. The implications of these findings are discussed.
- Publication
Cancer (0008543X), 1977, Vol 40, Issue 3, p1109
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197709)40:3<1109::AID-CNCR2820400320>3.0.CO;2-5