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- Title
The Gene for Bazex-Dupré-Christol Syndrome Maps to Chromosome Xq.
- Authors
Vabres, Pierre; Lacombe, Didier; Rabinowitz, Linda G.; Aubert, Gérard; Anderson, Carol E.; Taieb, Alain; Bonafe, Jean-Louis; Hors-Cayla, Marie-Claude
- Abstract
Bazex-Dupré-Christol syndrome is an inherited condition with skin cancer predisposition characterized by follicular atrophoderma, hypotrichosis, and early onset of multiple basal cell carcinomas. Previous reports suggested an X-linked mode of inheritance. We therefore performed linkage analysis with microsatellite markers of the X chromosome in three families. We obtained evidence for X-linkage and regional assignment to Xq24-q27 of this syndrome (maximal lod score = 5.26 with a recombination fraction of 0% at the DXSl192 locus). This represents a first step towards the identification of a gene involved in hair follicle development and skin tumor formation.
- Subjects
SKIN cancer; CHROMOSOMES; HAIR follicles; GENES; EPITHELIUM; MOLECULAR genetics
- Publication
Journal of Investigative Dermatology, 1995, Vol 105, Issue 1, p87
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12313359