We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Dendritic cells and toll-like receptors 2 and 4 in the ileum of Crohn's disease patients.
- Authors
Silva, Manuel A; Quera, Rodrigo; Valenzuela, Jorge; Salim, Sa'ad Y; Söderholm, Johan D; Perdue, Mary H
- Abstract
We investigated myeloid-dendritic cell (DC) marker and Toll-like receptor (TLR)-2 and 4 distributions in ileal samples from Crohn's disease (CD) patients (n = 14) and controls (n = 13). In controls, no TLR-2+ cells were observed, and higher numbers of TLR-4+ and DC-SIGN+ cells (P < 0.01) were detected in ileal samples when compared versus colonic tissues. In non-inflamed CD ileum, TLR-4+ and DC-SGN+ cells were depleted from superficial areas of the villus, and a significant CD1a+ cell infiltration (P < 0.01) was observed when compared to ileal controls and non-inflamed colonic CD samples. In inflamed CD ileum, DC-SIGN+, CD1a+, TLR-4+and few TLR-4+DC-SIGN+ cells were detected as well as CD83 depletion. No correlation between TLR-2 and DC markers was detected in CD samples. A unique distribution of myeloid-DC markers characterized the CD ileum. Also, the presence of significant amounts of ileal CD1a+ cells may provide a relevant DC-mediated mechanism for antigen recognition in the pathogenesis of CD.
- Subjects
ANALYSIS of variance; CELL receptors; DENDRITIC cells; CROHN'S disease; ILEUM; IMMUNOENZYME technique
- Publication
Digestive Diseases & Sciences, 2008, Vol 53, Issue 7, p1917
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-007-0105-x