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- Title
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
- Authors
Naj, Adam C.; Gyungah Jun; Beecham, Gary W.; Li-San Wang; Vardarajan, Badri Narayan; Buros, Jacqueline; Gallins, Paul J.; Buxbaum, Joseph D.; Jarvik, Gail P.; Crane, Paul K.; Larson, Eric B.; Bird, Thomas D.; Boeve, Bradley F.; Graff-Radford, Neill R.; De Jager, Philip L.; Evans, Denis; Schneider, Julie A.; Carrasquillo, Minerva M.; Ertekin-Taner, Nilufer; Younkin, Steven G.
- Abstract
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (PM) = 1.7 × 10−9, joint analysis P (PJ) = 1.7 × 10−9; stages 1, 2 and 3, PM = 8.2 × 10−12), CD2AP (rs9349407; stages 1, 2 and 3, PM = 8.6 × 10−9), EPHA1 (rs11767557; stages 1, 2 and 3, PM = 6.0 × 10−10) and CD33 (rs3865444; stages 1, 2 and 3, PM = 1.6 × 10−9). We also replicated previous associations at CR1 (rs6701713; PM = 4.6 × 10−10, PJ = 5.2 × 10−11), CLU (rs1532278; PM = 8.3 × 10−8, PJ = 1.9 × 10−8), BIN1 (rs7561528; PM = 4.0 × 10−14, PJ = 5.2 × 10−14) and PICALM (rs561655; PM = 7.0 × 10−11, PJ = 1.0 × 10−10), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.
- Subjects
ALZHEIMER'S disease research; NEURODEGENERATION; DISEASES in older people; META-analysis; EXPERIMENTAL design
- Publication
Nature Genetics, 2011, Vol 43, Issue 5, p436
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.801