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- Title
Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure.
- Authors
Newton-Cheh, Christopher; Larson, Martin G.; Vasan, Ramachandran S.; Levy, Daniel; Bloch, Kenneth D.; Surti, Aarti; Guiducci, Candace; Kathiresan, Sekar; Benjamin, Emelia J.; Struck, Joachim; Morgenthaler, Nils G.; Bergmann, Andreas; Blankenberg, Stefan; Kee, Frank; Nilsson, Peter; Xiaoyan Yin; Peltonen, Leena; Vartiainen, Erkki; Salomaa, Veikko; Hirschhorn, Joel N.
- Abstract
We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure–lowering properties. We genotyped SNPs at the NPPA-NPPB locus in 14,743 individuals of European ancestry, and identified associations of plasma atrial natriuretic peptide with rs5068 (P = 8 × 10−70), rs198358 (P = 8 × 10−30) and rs632793 (P = 2 × 10−10), and of plasma B-type natriuretic peptide with rs5068 (P = 3 × 10−12), rs198358 (P = 1 × 10−25) and rs632793 (P = 2 × 10−68). In 29,717 individuals, the alleles of rs5068 and rs198358 that showed association with increased circulating natriuretic peptide concentrations were also found to be associated with lower systolic (P = 2 × 10−6 and 6 × 10−5, respectively) and diastolic blood pressure (P = 1 × 10−6 and 5 × 10−5), as well as reduced odds of hypertension (OR = 0.85, 95% CI = 0.79–0.92, P = 4 × 10−5; OR = 0.90, 95% CI = 0.85–0.95, P = 2 × 10−4, respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension.
- Subjects
ATRIAL natriuretic peptides; BLOOD pressure; HEART atrium; HYPERTENSION; DISEASE risk factors; GENETIC research
- Publication
Nature Genetics, 2009, Vol 41, Issue 3, p348
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.328