We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Identification of loci associated with schizophrenia by genome-wide association and follow-up.
- Authors
Michael C. O'Donovan; Nicholas Craddock; Nadine Norton; Hywel Williams; Timothy Peirce; Valentina Moskvina; Ivan Nikolov; Marian Hamshere; Liam Carroll; Lyudmila Georgieva; Sarah Dwyer; Peter Holmans; Jonathan L. Marchini; Chris C. A. Spencer; Bryan Howie; Hin-Tak Leung; Annette M. Hartmann; Hans-Jürgen Möller; Derek W. Morris; YongYong Shi
- Abstract
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10−5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 × 10−4), and the overall pattern of replication was unlikely to occur by chance (P = 9 × 10−8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 × 10−7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 × 10−9).
- Subjects
PSYCHOSES; SCHIZOPHRENIA; BIPOLAR disorder; META-analysis; GENETICS
- Publication
Nature Genetics, 2008, Vol 40, Issue 9, p1053
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.201