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- Title
Revisiting the role of pregnancy zone protein (PZP) as a cancer biomarker in the immunotherapy era.
- Authors
Huang, Jie; Xu, Ying; Chen, Yidan; Shen, Juan; Qiu, Yao; Li, Xin; Chen, Xueqin; Ma, Shenglin
- Abstract
This document, titled "Revisiting the role of pregnancy zone protein (PZP) as a cancer biomarker in the immunotherapy era," discusses the potential use of pregnancy zone protein (PZP) as a biomarker in cancer diagnosis, prognosis, and therapy response evaluation. The authors conducted a pan-cancer analysis of PZP expression levels and found that PZP expression varied among different cancer types. They also discovered that PZP expression was correlated with immune checkpoint genes and immune cell subtypes in the tumor microenvironment. Additionally, the study revealed that higher PZP expression was associated with better response to anti-PD1 or anti-CTLA4 immunotherapy. The authors suggest that PZP may serve as a new biomarker for guiding immunotherapy in cancer treatment.
- Subjects
PREGNANCY proteins; TUMOR markers; BIOMARKERS; IMMUNOTHERAPY; RECURRENT miscarriage
- Publication
Journal of Translational Medicine, 2024, Vol 22, Issue 1, p1
- ISSN
1479-5876
- Publication type
Article
- DOI
10.1186/s12967-024-05321-5