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- Title
Structure of the activating IL-1 receptor signaling complex.
- Authors
Thomas, Christoph; Bazan, J Fernando; Garcia, K Christopher
- Abstract
Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity. They exert proinflammatory effects by binding a primary receptor that recruits a receptor accessory protein to form a signaling-competent heterotrimeric complex. Here we present the crystal structure of IL-1? bound to its primary receptor IL-1RI and its receptor accessory protein IL-1RAcP, providing insight into how IL-1-type cytokines initiate signaling and revealing an evolutionary relationship with the fibroblast growth factor receptor family.
- Subjects
INTERLEUKIN-1; FIBROBLAST growth factors; IR genes; CYTOKINES; IMMUNOMODULATORS
- Publication
Nature Structural & Molecular Biology, 2012, Vol 19, Issue 4, p455
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2260