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- Title
Characteristics of Novel Insect Defensin-Based Membrane-Disrupting Trypanocidal Peptides.
- Authors
Yamage, Mat; Yoshiyama, Mikio; Grab, Dennis J.; Kubo, Masanori; Iwasaki, Takashi; Kitani, Hiroshi; Ishibashi, Jun; Yamakawa, Monoru
- Abstract
The article presents a study on the ability of synthetic D- and L-amino acid type cationic 9-mer peptides from insect defensins to modify the growth of blood-stream form African trypanosomes in vitro. It notes that the antimicrobial peptides defensin and attacin have been shown to be important in the reduction of African trypanosomes in the tsetse fly. It concludes that insect defensin-based peptides represent a new class of membrane-disrupting trypanocidal drugs.
- Subjects
AMINO acids; ANTIMICROBIAL peptides; TSETSE-flies; PEPTIDES; DRUG development
- Publication
Bioscience, Biotechnology & Biochemistry, 2009, Vol 73, Issue 7, p1520
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.90004